Periventricular white matter lucencies in senile dementia of the Alzheimer type and in normal aging

Donald L. Rezek, John C. Morris, Keith H. Fulling, Mokhtar H. Gado

Research output: Contribution to journalArticlepeer-review

165 Scopus citations

Abstract

The significance of periventricular lucencies in the white matter on CT in demented patients is not understood. We studied the relationship of these changes to mental status of subjects with senile dementia of the Alzheimer type. A semiquantitative method showed more numerous and extensive lucencies in demented than in healthy elderly. Neuropathologic examination of five subjects with these changes and confirmed Alzheimer’s disease revealed diffuse white matter pallor without infarction. There were no hypertensive vascular changes, although limited hyaline thickening was present.

Original languageEnglish
Pages (from-to)1365-1368
Number of pages4
JournalNeurology
Volume37
Issue number8
DOIs
StatePublished - Aug 1987

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