Peripheral neuropathy in ART-experienced patients: Prevalence and risk factors

Huichao Chen; David B. Clifford; Lijuan Deng; Kunling Wu; Anthony J. Lee; Ronald J. Bosch; Sharon A. Riddler; Ronald J. Ellis; Scott R. Evans

doi:10.1007/s13365-013-0216-4

Peripheral neuropathy in ART-experienced patients: Prevalence and risk factors

Huichao Chen
, David B. Clifford
, Lijuan Deng
, Kunling Wu
, Anthony J. Lee
, Ronald J. Bosch
, Sharon A. Riddler
, Ronald J. Ellis
, Scott R. Evans

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Peripheral neuropathy (PN) is a common neurological complication of HIV infection that has debilitating effects on quality of life. While there has been a comprehensive evaluation of the prevalence of neuropathic signs/symptoms and risk factors (RFs) for PN or symptomatic PN (SPN) with initiation of combination antiretroviral therapy (cART) in ART-naïve patients, similar evaluation in ART-experienced patients is limited. This study investigated the prevalence and RFs for PN/SPN in ART-experienced patients enrolled in clinical salvage therapy studies. Between February 2000 and June 2007, 522 ART-experienced participants who experienced virologic failure with a prior regimen and started new regimens were followed longitudinally and annually screened for signs and symptoms of PN. Rates of PN/SPN at 3 years since parent study entry were 52.8 and 24.0 %, respectively. Aging, taller height, protease inhibitor use, and female sex were significant RFs for PN/SPN. The use of statin drugs was significantly associated with lower odds of SPN, and it may prevent progression from no SPN to SPN.

Original language	English
Pages (from-to)	557-564
Number of pages	8
Journal	Journal of NeuroVirology
Volume	19
Issue number	6
DOIs	https://doi.org/10.1007/s13365-013-0216-4
State	Published - Dec 2013

Keywords

HIV infection
Peripheral neuropathy
Risk factors
Symptomatic peripheral neuropathy

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10.1007/s13365-013-0216-4

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title = "Peripheral neuropathy in ART-experienced patients: Prevalence and risk factors",

abstract = "Peripheral neuropathy (PN) is a common neurological complication of HIV infection that has debilitating effects on quality of life. While there has been a comprehensive evaluation of the prevalence of neuropathic signs/symptoms and risk factors (RFs) for PN or symptomatic PN (SPN) with initiation of combination antiretroviral therapy (cART) in ART-na{\"i}ve patients, similar evaluation in ART-experienced patients is limited. This study investigated the prevalence and RFs for PN/SPN in ART-experienced patients enrolled in clinical salvage therapy studies. Between February 2000 and June 2007, 522 ART-experienced participants who experienced virologic failure with a prior regimen and started new regimens were followed longitudinally and annually screened for signs and symptoms of PN. Rates of PN/SPN at 3 years since parent study entry were 52.8 and 24.0 \%, respectively. Aging, taller height, protease inhibitor use, and female sex were significant RFs for PN/SPN. The use of statin drugs was significantly associated with lower odds of SPN, and it may prevent progression from no SPN to SPN.",

keywords = "HIV infection, Peripheral neuropathy, Risk factors, Symptomatic peripheral neuropathy",

author = "Huichao Chen and Clifford, \{David B.\} and Lijuan Deng and Kunling Wu and Lee, \{Anthony J.\} and Bosch, \{Ronald J.\} and Riddler, \{Sharon A.\} and Ellis, \{Ronald J.\} and Evans, \{Scott R.\}",

note = "Funding Information: This work was supported by National Institute of Health (NIH) grants including the Neurologic AIDS Research Consortium grant NS32228 from NINDS, the AIDS Clinical Trials Grant AI068636 from NIAID, and the Statistical and Data Management Center of the Adult AIDS Clinical Trials Group grant 1 U01 068634. The authors acknowledge the generous dedication of the many participants volunteering for the ALLRT study, and for the contributions of the contributing AIDS Clinical Trials Units, their investigators and staffs, that collected the samples and clinical data used for this analysis. The authors would like to thank reviewers for their thoughtful comments. ",

year = "2013",

month = dec,

doi = "10.1007/s13365-013-0216-4",

language = "English",

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journal = "Journal of NeuroVirology",

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T2 - Prevalence and risk factors

AU - Chen, Huichao

AU - Clifford, David B.

AU - Deng, Lijuan

AU - Wu, Kunling

AU - Lee, Anthony J.

AU - Bosch, Ronald J.

AU - Riddler, Sharon A.

AU - Ellis, Ronald J.

AU - Evans, Scott R.

N1 - Funding Information: This work was supported by National Institute of Health (NIH) grants including the Neurologic AIDS Research Consortium grant NS32228 from NINDS, the AIDS Clinical Trials Grant AI068636 from NIAID, and the Statistical and Data Management Center of the Adult AIDS Clinical Trials Group grant 1 U01 068634. The authors acknowledge the generous dedication of the many participants volunteering for the ALLRT study, and for the contributions of the contributing AIDS Clinical Trials Units, their investigators and staffs, that collected the samples and clinical data used for this analysis. The authors would like to thank reviewers for their thoughtful comments.

PY - 2013/12

Y1 - 2013/12

N2 - Peripheral neuropathy (PN) is a common neurological complication of HIV infection that has debilitating effects on quality of life. While there has been a comprehensive evaluation of the prevalence of neuropathic signs/symptoms and risk factors (RFs) for PN or symptomatic PN (SPN) with initiation of combination antiretroviral therapy (cART) in ART-naïve patients, similar evaluation in ART-experienced patients is limited. This study investigated the prevalence and RFs for PN/SPN in ART-experienced patients enrolled in clinical salvage therapy studies. Between February 2000 and June 2007, 522 ART-experienced participants who experienced virologic failure with a prior regimen and started new regimens were followed longitudinally and annually screened for signs and symptoms of PN. Rates of PN/SPN at 3 years since parent study entry were 52.8 and 24.0 %, respectively. Aging, taller height, protease inhibitor use, and female sex were significant RFs for PN/SPN. The use of statin drugs was significantly associated with lower odds of SPN, and it may prevent progression from no SPN to SPN.

AB - Peripheral neuropathy (PN) is a common neurological complication of HIV infection that has debilitating effects on quality of life. While there has been a comprehensive evaluation of the prevalence of neuropathic signs/symptoms and risk factors (RFs) for PN or symptomatic PN (SPN) with initiation of combination antiretroviral therapy (cART) in ART-naïve patients, similar evaluation in ART-experienced patients is limited. This study investigated the prevalence and RFs for PN/SPN in ART-experienced patients enrolled in clinical salvage therapy studies. Between February 2000 and June 2007, 522 ART-experienced participants who experienced virologic failure with a prior regimen and started new regimens were followed longitudinally and annually screened for signs and symptoms of PN. Rates of PN/SPN at 3 years since parent study entry were 52.8 and 24.0 %, respectively. Aging, taller height, protease inhibitor use, and female sex were significant RFs for PN/SPN. The use of statin drugs was significantly associated with lower odds of SPN, and it may prevent progression from no SPN to SPN.

KW - HIV infection

KW - Peripheral neuropathy

KW - Risk factors

KW - Symptomatic peripheral neuropathy

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JF - Journal of NeuroVirology

IS - 6

ER -

Peripheral neuropathy in ART-experienced patients: Prevalence and risk factors

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Keywords

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