Peripheral Neuropathy as a Component of Skeletal Disease in Diabetes

Alec T. Beeve, Jennifer M. Brazill, Erica L. Scheller

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Purpose of Review: The goal of this review is to explore clinical associations between peripheral neuropathy and diabetic bone disease and to discuss how nerve dysfunction may contribute to dysregulation of bone metabolism, reduced bone quality, and fracture risk. Recent Findings: Diabetic neuropathy can decrease peripheral sensation (sensory neuropathy), impair motor coordination (motor neuropathy), and increase postural hypotension (autonomic neuropathy). Together, this can impair overall balance and increase the risk for falls and fractures. In addition, the peripheral nervous system has the potential to regulate bone metabolism directly through the action of local neurotransmitters on bone cells and indirectly through neuroregulation of the skeletal vascular supply. Summary: This review critically evaluates existing evidence for diabetic peripheral neuropathy as a risk factor or direct actor on bone disease. In addition, we address therapeutic and experimental considerations to guide patient care and future research evaluating the emerging relationship between diabetic neuropathy and bone health.

Original languageEnglish
Pages (from-to)256-269
Number of pages14
JournalCurrent Osteoporosis Reports
Volume17
Issue number5
DOIs
StatePublished - Oct 1 2019

Keywords

  • Diabetes
  • Fracture
  • Marrow adiposity
  • Marrow fat
  • Metabolic bone disease
  • Microvascular disease
  • Neuropathy

Fingerprint

Dive into the research topics of 'Peripheral Neuropathy as a Component of Skeletal Disease in Diabetes'. Together they form a unique fingerprint.

Cite this