Peripheral nerve injury by chymopapain injection

S. E. Mackinnon, A. R. Hudson, F. Llamas, A. L. Dellon, D. G. Kline, D. A. Hunter

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Chymopapain injected into the intervertebral disc (chemonucleolysis) has been used clinically in patients with disc disease with success. Neurosurgical complications secondary to the procedure have, however, been reported. In this study, the authors have investigated the possible neurotoxic effect of chymopapain on the peripheral nerve in rat and primate models. While the extrafascicular injection caused no nerve fiber damage, the intrafascicular injection caused dose-related nerve fiber damage in both species.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalJournal of neurosurgery
Volume61
Issue number1
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

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    Mackinnon, S. E., Hudson, A. R., Llamas, F., Dellon, A. L., Kline, D. G., & Hunter, D. A. (1984). Peripheral nerve injury by chymopapain injection. Journal of neurosurgery, 61(1), 1-8. https://doi.org/10.3171/jns.1984.61.1.0001