Peripheral nerve injection injury with purified bovine collagen - an experimental model in the rat

S. E. Mackinnon, A. R. Hudson, V. Bojanowski, D. A. Hunter, E. Maraghi

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

This study investigated the effect of purified bovine collagen (Zyderm collagen implant) on peripheral nerve tissue in rats. Zyderm was injected extrafascicularly and intrafascicularly into the sciatic nerve of adult Wistar rats. The nerves were examined by light and electron microscopy and the integrity of the blood-nerve barrier was assessed by protein tracer technique. With light microscopy, the precise anatomical location of the injected material could be identified. The purified bovine collagen did not appear to be neurotoxic. After extrafascicular injection, only minimal nerve fiber damage was seen. Intrafascicular injection produced a histological picture compatible with compression neuropathy and was associated with a breakdown in the blood-nerve barrier.

Original languageEnglish
Pages (from-to)428-436
Number of pages9
JournalAnnals of Plastic Surgery
Volume14
Issue number5
DOIs
StatePublished - Dec 18 1985

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