Peripheral nerve allograft: An immunological assessment of pretreatment methods

S. E. Mackinnon, A. R. Hudson, R. E. Falk, D. Kline, D. Hunter

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

An in vivo immunological assay was used to determine quantitatively the nerve allograft response in a rat model. The nerve allograft was then pretreated with a number of pretreatment methods that have been used clinically and experimentally. Using the same immunological assay to determine quantitatively the nerve allograft response, we found that lyophilization and high doses of irradiation could modify the nerve allograft in such a way as to make it less immunogenetic to the host animal. The other methods of pretreatment did not alter the antigenicity of the allograft.

Original languageEnglish
Pages (from-to)167-171
Number of pages5
JournalNeurosurgery
Volume14
Issue number2
DOIs
StatePublished - 1984

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