Peripheral Mechanisms of Itch

Changxiong J. Guo; Nathaniel S. Grabinski; Qin Liu

doi:10.1016/j.jid.2021.10.024

Peripheral Mechanisms of Itch

Changxiong J. Guo
, Nathaniel S. Grabinski
, Qin Liu

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

Itch is a universally experienced sensation, and chronic itch can be as diabolically debilitating as pain. Recent advances have not only identified the neuronal itch sensing circuitry, but also have uncovered the intricate interactions between skin and immune cells that work together with neurons to identify itch-inducing irritants. In this review, we will summarize the fundamental mechanisms of acute itch detection in the skin, as well as highlight the recent discoveries relating to this topic.

Original language	English
Pages (from-to)	31-41
Number of pages	11
Journal	Journal of Investigative Dermatology
Volume	142
Issue number	1
DOIs	https://doi.org/10.1016/j.jid.2021.10.024
State	Published - Jan 2022

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10.1016/j.jid.2021.10.024

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title = "Peripheral Mechanisms of Itch",

abstract = "Itch is a universally experienced sensation, and chronic itch can be as diabolically debilitating as pain. Recent advances have not only identified the neuronal itch sensing circuitry, but also have uncovered the intricate interactions between skin and immune cells that work together with neurons to identify itch-inducing irritants. In this review, we will summarize the fundamental mechanisms of acute itch detection in the skin, as well as highlight the recent discoveries relating to this topic.",

author = "Guo, \{Changxiong J.\} and Grabinski, \{Nathaniel S.\} and Qin Liu",

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year = "2022",

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language = "English",

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AU - Grabinski, Nathaniel S.

AU - Liu, Qin

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N2 - Itch is a universally experienced sensation, and chronic itch can be as diabolically debilitating as pain. Recent advances have not only identified the neuronal itch sensing circuitry, but also have uncovered the intricate interactions between skin and immune cells that work together with neurons to identify itch-inducing irritants. In this review, we will summarize the fundamental mechanisms of acute itch detection in the skin, as well as highlight the recent discoveries relating to this topic.

AB - Itch is a universally experienced sensation, and chronic itch can be as diabolically debilitating as pain. Recent advances have not only identified the neuronal itch sensing circuitry, but also have uncovered the intricate interactions between skin and immune cells that work together with neurons to identify itch-inducing irritants. In this review, we will summarize the fundamental mechanisms of acute itch detection in the skin, as well as highlight the recent discoveries relating to this topic.

UR - https://www.scopus.com/pages/publications/85119902647

U2 - 10.1016/j.jid.2021.10.024

DO - 10.1016/j.jid.2021.10.024

M3 - Review article

C2 - 34838258

AN - SCOPUS:85119902647

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VL - 142

SP - 31

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JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

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ER -

Peripheral Mechanisms of Itch

Abstract

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