Peripheral Mechanisms of Itch

Changxiong J. Guo, Nathaniel S. Grabinski, Qin Liu

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Itch is a universally experienced sensation, and chronic itch can be as diabolically debilitating as pain. Recent advances have not only identified the neuronal itch sensing circuitry, but also have uncovered the intricate interactions between skin and immune cells that work together with neurons to identify itch-inducing irritants. In this review, we will summarize the fundamental mechanisms of acute itch detection in the skin, as well as highlight the recent discoveries relating to this topic.

Original languageEnglish
Pages (from-to)31-41
Number of pages11
JournalJournal of Investigative Dermatology
Volume142
Issue number1
DOIs
StatePublished - Jan 2022

Fingerprint

Dive into the research topics of 'Peripheral Mechanisms of Itch'. Together they form a unique fingerprint.

Cite this