TY - JOUR
T1 - Peripheral Mechanisms of Itch
AU - Guo, Changxiong J.
AU - Grabinski, Nathaniel S.
AU - Liu, Qin
N1 - Funding Information:
The authors would like to thank Xingzhong Dong, Lian Han, Brian Kim, and Michael Panneton for their thoughtful critiques of this paper. Their invaluable feedback greatly improved the quality of this manuscript. Visualization: CJG, NSG; Supervision: QL; Writing - Original Draft Preparation: CJG, NSG; Writing - Review and Editing: CJG, NSG, QL
Publisher Copyright:
© 2021 The Authors
PY - 2022/1
Y1 - 2022/1
N2 - Itch is a universally experienced sensation, and chronic itch can be as diabolically debilitating as pain. Recent advances have not only identified the neuronal itch sensing circuitry, but also have uncovered the intricate interactions between skin and immune cells that work together with neurons to identify itch-inducing irritants. In this review, we will summarize the fundamental mechanisms of acute itch detection in the skin, as well as highlight the recent discoveries relating to this topic.
AB - Itch is a universally experienced sensation, and chronic itch can be as diabolically debilitating as pain. Recent advances have not only identified the neuronal itch sensing circuitry, but also have uncovered the intricate interactions between skin and immune cells that work together with neurons to identify itch-inducing irritants. In this review, we will summarize the fundamental mechanisms of acute itch detection in the skin, as well as highlight the recent discoveries relating to this topic.
UR - http://www.scopus.com/inward/record.url?scp=85119902647&partnerID=8YFLogxK
U2 - 10.1016/j.jid.2021.10.024
DO - 10.1016/j.jid.2021.10.024
M3 - Review article
C2 - 34838258
AN - SCOPUS:85119902647
VL - 142
SP - 31
EP - 41
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 1
ER -