TY - JOUR
T1 - Peripheral Blood Epstein–Barr Viral Nucleic Acid Surveillance as a Marker for Posttransplant Cancer Risk
AU - Dharnidharka, V. R.
N1 - Funding Information:
The author presented some of this material at an invited oral lecture on “Oncogenic Viral Surveillance” as part of a symposium on “Immunomodulators and Cancer Risk Assessment” sponsored by the U.S. Food and Drug Administration at its White Oak campus in Washington DC, USA on October 21–22, 2014. The material in this manuscript has not been published previously or elsewhere.
Publisher Copyright:
© Copyright 2016 The American Society of Transplantation and the American Society of Transplant Surgeons
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Several viruses, such as Epstein–Barr virus, are now known to be associated with several human cancers, but not all patients with these viral infections develop cancer. In transplantation, such viruses often have a prolonged time gap from infection to cancer development, and many are preceded by a period of circulating and detectable nucleic acids in the peripheral blood compartment. The interpretation of a viral load as a measure of posttransplant risk of developing cancer depends on the virus, the cancer and associated pathogenic factors. This review describes the current state of knowledge regarding the utility and limitations of peripheral blood nucleic acid testing for Epstein–Barr virus in surveillance and risk prediction for posttransplant lymphoproliferative disorders.
AB - Several viruses, such as Epstein–Barr virus, are now known to be associated with several human cancers, but not all patients with these viral infections develop cancer. In transplantation, such viruses often have a prolonged time gap from infection to cancer development, and many are preceded by a period of circulating and detectable nucleic acids in the peripheral blood compartment. The interpretation of a viral load as a measure of posttransplant risk of developing cancer depends on the virus, the cancer and associated pathogenic factors. This review describes the current state of knowledge regarding the utility and limitations of peripheral blood nucleic acid testing for Epstein–Barr virus in surveillance and risk prediction for posttransplant lymphoproliferative disorders.
KW - complication: malignant
KW - infection and infectious agents
KW - infectious disease
KW - posttransplant lymphoproliferative disorder (PTLD)
KW - side effects
KW - translational research/science
KW - viral: Epstein-Barr Virus (EBV)
UR - http://www.scopus.com/inward/record.url?scp=84992154002&partnerID=8YFLogxK
U2 - 10.1111/ajt.13982
DO - 10.1111/ajt.13982
M3 - Review article
C2 - 27458691
AN - SCOPUS:84992154002
SN - 1600-6135
VL - 17
SP - 611
EP - 616
JO - American Journal of Transplantation
JF - American Journal of Transplantation
IS - 3
ER -