Peripartum Cardiomyopathy: Progress in Understanding the Etiology, Management, and Prognosis

Kathryn J. Lindley, Amanda K. Verma, Lori A. Blauwet

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Occurring in approximately 1 in 1000 live births in the United States, peripartum cardiomyopathy (PPCM) is characterized by left ventricular ejection fraction reduced to less than 45% near the end of pregnancy or within the first 5 months after delivery. Although the cause of PPCM remains unclear, increasing evidence supports a complex interaction of genetic and environmental factors contributing to angiogenic imbalance, which may lead to myocardial dysfunction in a susceptible woman. This article reviews the progress that has been made regarding understanding of the cause, management, and natural history of PPCM.

Original languageEnglish
Pages (from-to)29-39
Number of pages11
JournalHeart Failure Clinics
Issue number1
StatePublished - Jan 2019


  • Diagnosis
  • Heart failure
  • Peripartum cardiomyopathy
  • Pregnancy
  • Prognosis


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