Perioperative pharmacokinetics of methadone in adolescents

Anshuman Sharma; Danielle Tallchief; Jane Blood; Thomas Kim; Amy London; Evan D. Kharasch

doi:10.1097/ALN.0b013e318238fec5

Perioperative pharmacokinetics of methadone in adolescents

Anshuman Sharma, Danielle Tallchief, Jane Blood, Thomas Kim, Amy London, Evan D. Kharasch

Department of Anesthesiology

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Background: Methadone is frequently administered to adults experiencing anesthesia and receiving pain treatment. Methadone pharmacokinetics in adults are well characterized, including the perioperative period. Methadone is also used in children. There is, however, no information on methadone pharmacokinetics in children of any age. The purpose of this investigation was to determine the pharmacokinetics of intravenous methadone in children undergoing surgery. Perioperative opioid-sparing effects were also assessed.

Original language	English
Pages (from-to)	1153-1161
Number of pages	9
Journal	Anesthesiology
Volume	115
Issue number	6
DOIs	https://doi.org/10.1097/ALN.0b013e318238fec5
State	Published - Dec 2011

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10.1097/ALN.0b013e318238fec5

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abstract = "Background: Methadone is frequently administered to adults experiencing anesthesia and receiving pain treatment. Methadone pharmacokinetics in adults are well characterized, including the perioperative period. Methadone is also used in children. There is, however, no information on methadone pharmacokinetics in children of any age. The purpose of this investigation was to determine the pharmacokinetics of intravenous methadone in children undergoing surgery. Perioperative opioid-sparing effects were also assessed.",

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AB - Background: Methadone is frequently administered to adults experiencing anesthesia and receiving pain treatment. Methadone pharmacokinetics in adults are well characterized, including the perioperative period. Methadone is also used in children. There is, however, no information on methadone pharmacokinetics in children of any age. The purpose of this investigation was to determine the pharmacokinetics of intravenous methadone in children undergoing surgery. Perioperative opioid-sparing effects were also assessed.

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Perioperative pharmacokinetics of methadone in adolescents

Abstract

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