Perioperative pharmacokinetics of methadone in adolescents

Anshuman Sharma, Danielle Tallchief, Jane Blood, Thomas Kim, Amy London, Evan D. Kharasch

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Background: Methadone is frequently administered to adults experiencing anesthesia and receiving pain treatment. Methadone pharmacokinetics in adults are well characterized, including the perioperative period. Methadone is also used in children. There is, however, no information on methadone pharmacokinetics in children of any age. The purpose of this investigation was to determine the pharmacokinetics of intravenous methadone in children undergoing surgery. Perioperative opioid-sparing effects were also assessed.

Original languageEnglish
Pages (from-to)1153-1161
Number of pages9
Issue number6
StatePublished - Dec 2011


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