TY - JOUR
T1 - Periodontal disease and adverse pregnancy outcomes
T2 - is there an association?
AU - Srinivas, Sindhu K.
AU - Sammel, Mary D.
AU - Stamilio, David M.
AU - Clothier, Bonnie
AU - Jeffcoat, Marjorie K.
AU - Parry, Samuel
AU - Macones, George A.
AU - Elovitz, Michal A.
AU - Metlay, Joshua
N1 - Funding Information:
This research was supported by a Pennsylvania Department of Health Grant and an NIH T32 Training Grant.
PY - 2009/5
Y1 - 2009/5
N2 - Objective: We assessed the risk of adverse pregnancy outcomes (preterm birth [PTB], preeclampsia [PRE], fetal growth restriction [FGR], or perinatal death) in women with periodontal disease (PD) compared to those without. Study Design: A multicenter prospective cohort study enrolled women from 3 sites between 6 and 20 weeks' gestation. The presence of PD was defined as periodontal attachment loss ≥ to 3 mm on 3 or more teeth. The primary binary composite outcome included PRE, PTB, FGR, or perinatal death. Multivariable logistic regression (MVLR) was used to control for confounders. Results: Three hundred eleven patients with and 475 without PD were included. There was no association between PD and the composite outcome, PRE, or PTB in unadjusted analyses. There was no association between PD and the composite outcome (adjusted odds ratio [AOR], 0.81; 95% confidence interval [CI], 0.58-1.15; P = .24), preeclampsia (AOR, 0.71; 95% CI, 0.37-1.36; P = .30), or preterm birth (AOR, 0.77; 95% CI, 0.49-1.21; P = .25) after adjusting for relevant confounders. Conclusion: Despite the body of literature suggesting an association between PD and adverse pregnancy outcomes in urban populations, this large prospective study failed to demonstrate an association.
AB - Objective: We assessed the risk of adverse pregnancy outcomes (preterm birth [PTB], preeclampsia [PRE], fetal growth restriction [FGR], or perinatal death) in women with periodontal disease (PD) compared to those without. Study Design: A multicenter prospective cohort study enrolled women from 3 sites between 6 and 20 weeks' gestation. The presence of PD was defined as periodontal attachment loss ≥ to 3 mm on 3 or more teeth. The primary binary composite outcome included PRE, PTB, FGR, or perinatal death. Multivariable logistic regression (MVLR) was used to control for confounders. Results: Three hundred eleven patients with and 475 without PD were included. There was no association between PD and the composite outcome, PRE, or PTB in unadjusted analyses. There was no association between PD and the composite outcome (adjusted odds ratio [AOR], 0.81; 95% confidence interval [CI], 0.58-1.15; P = .24), preeclampsia (AOR, 0.71; 95% CI, 0.37-1.36; P = .30), or preterm birth (AOR, 0.77; 95% CI, 0.49-1.21; P = .25) after adjusting for relevant confounders. Conclusion: Despite the body of literature suggesting an association between PD and adverse pregnancy outcomes in urban populations, this large prospective study failed to demonstrate an association.
KW - adverse outcomes
KW - periodontal disease
KW - pregnancy
KW - preterm birth
UR - http://www.scopus.com/inward/record.url?scp=64249140091&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2009.03.003
DO - 10.1016/j.ajog.2009.03.003
M3 - Article
C2 - 19375568
AN - SCOPUS:64249140091
SN - 0002-9378
VL - 200
SP - 497.e1-497.e8
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 5
ER -