Periodic loss of reactivity of a myeloma tumor with cytotoxic thymus-derived lymphocytes

J. H. Russell, A. H. Hale, L. C. Ginns, H. N. Eisen

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

During each transplantation passage of a line of mouse myeloma tumor MOPC-315 through syngeneic (BALB/c) hosts, the tumor cells lose reactivity with cytotoxic thymus-derived lymphocytes directed against products of the BALB/c major histocompatibility complex (H-2(d)) and regain reactivity on transfer to fresh hosts. In contrast to this cyclical change, the tumor cells remain uniformly reactive with anti-H-2(d) alloantisera throughout the transplantation cycle.

Original languageEnglish
Pages (from-to)441-445
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume75
Issue number1
DOIs
StatePublished - 1978

Fingerprint

Dive into the research topics of 'Periodic loss of reactivity of a myeloma tumor with cytotoxic thymus-derived lymphocytes'. Together they form a unique fingerprint.

Cite this