Periodic loss of reactivity of a myeloma tumor with cytotoxic thymus-derived lymphocytes

J. H. Russell; A. H. Hale; L. C. Ginns; H. N. Eisen

doi:10.1073/pnas.75.1.441

Periodic loss of reactivity of a myeloma tumor with cytotoxic thymus-derived lymphocytes

J. H. Russell, A. H. Hale, L. C. Ginns, H. N. Eisen

Department of Developmental Biology

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

During each transplantation passage of a line of mouse myeloma tumor MOPC-315 through syngeneic (BALB/c) hosts, the tumor cells lose reactivity with cytotoxic thymus-derived lymphocytes directed against products of the BALB/c major histocompatibility complex (H-2(d)) and regain reactivity on transfer to fresh hosts. In contrast to this cyclical change, the tumor cells remain uniformly reactive with anti-H-2(d) alloantisera throughout the transplantation cycle.

Original language	English
Pages (from-to)	441-445
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	75
Issue number	1
DOIs	https://doi.org/10.1073/pnas.75.1.441
State	Published - 1978

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title = "Periodic loss of reactivity of a myeloma tumor with cytotoxic thymus-derived lymphocytes",

abstract = "During each transplantation passage of a line of mouse myeloma tumor MOPC-315 through syngeneic (BALB/c) hosts, the tumor cells lose reactivity with cytotoxic thymus-derived lymphocytes directed against products of the BALB/c major histocompatibility complex (H-2(d)) and regain reactivity on transfer to fresh hosts. In contrast to this cyclical change, the tumor cells remain uniformly reactive with anti-H-2(d) alloantisera throughout the transplantation cycle.",

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AU - Eisen, H. N.

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AB - During each transplantation passage of a line of mouse myeloma tumor MOPC-315 through syngeneic (BALB/c) hosts, the tumor cells lose reactivity with cytotoxic thymus-derived lymphocytes directed against products of the BALB/c major histocompatibility complex (H-2(d)) and regain reactivity on transfer to fresh hosts. In contrast to this cyclical change, the tumor cells remain uniformly reactive with anti-H-2(d) alloantisera throughout the transplantation cycle.

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ER -

Periodic loss of reactivity of a myeloma tumor with cytotoxic thymus-derived lymphocytes

Abstract

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