TY - JOUR
T1 - Perinatal outcomes in women with preeclampsia and superimposed preeclampsia
T2 - Do they differ?
AU - Tuuli, Methodius G.
AU - Rampersad, Roxane
AU - Stamilio, David
AU - MacOnes, George
AU - Odibo, Anthony O.
PY - 2011/6
Y1 - 2011/6
N2 - Objective: The purpose of this study was to determine whether superimposed preeclampsia results in worse perinatal outcomes than preeclampsia. Study Design: We conducted a retrospective cohort study using our perinatal database (1990-2008). Perinatal outcomes among women with chronic hypertension (n = 1032), superimposed preeclampsia (n = 489), and preeclampsia (n = 4217) were compared with outcomes of control subjects (n = 57,103). Outcomes among women with superimposed preeclampsia were also compared with outcomes of women with preeclampsia. Multivariable analysis was used to control for confounders. Results: Rates of small-for-gestational age, abruption, stillbirth, and eclampsia were not significantly different with superimposed preeclampsia compared with preeclampsia. Delivery at <34 weeks' gestation (17.3% vs 8.7%; P < .001), cesarean delivery (46.2% vs 36.3%; P < .001), and neonatal intensive care unit admission (16.3% vs 11.4%; P < .002) were significantly higher among women with superimposed preeclampsia. These risks persisted after we controlled for confounders. Conclusion: Women with superimposed preeclampsia have higher risks of intervention-related events compared with those with preeclampsia.
AB - Objective: The purpose of this study was to determine whether superimposed preeclampsia results in worse perinatal outcomes than preeclampsia. Study Design: We conducted a retrospective cohort study using our perinatal database (1990-2008). Perinatal outcomes among women with chronic hypertension (n = 1032), superimposed preeclampsia (n = 489), and preeclampsia (n = 4217) were compared with outcomes of control subjects (n = 57,103). Outcomes among women with superimposed preeclampsia were also compared with outcomes of women with preeclampsia. Multivariable analysis was used to control for confounders. Results: Rates of small-for-gestational age, abruption, stillbirth, and eclampsia were not significantly different with superimposed preeclampsia compared with preeclampsia. Delivery at <34 weeks' gestation (17.3% vs 8.7%; P < .001), cesarean delivery (46.2% vs 36.3%; P < .001), and neonatal intensive care unit admission (16.3% vs 11.4%; P < .002) were significantly higher among women with superimposed preeclampsia. These risks persisted after we controlled for confounders. Conclusion: Women with superimposed preeclampsia have higher risks of intervention-related events compared with those with preeclampsia.
KW - adverse perinatal outcome
KW - chronic hypertension
KW - preeclampsia
KW - superimposed preeclampsia
UR - http://www.scopus.com/inward/record.url?scp=79958092524&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2011.01.065
DO - 10.1016/j.ajog.2011.01.065
M3 - Article
C2 - 21419381
AN - SCOPUS:79958092524
SN - 0002-9378
VL - 204
SP - 508.e1-508.e7
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 6
ER -