Perinatal outcomes in women with preeclampsia and superimposed preeclampsia: Do they differ?

Methodius G. Tuuli, Roxane Rampersad, David Stamilio, George MacOnes, Anthony O. Odibo

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Objective: The purpose of this study was to determine whether superimposed preeclampsia results in worse perinatal outcomes than preeclampsia. Study Design: We conducted a retrospective cohort study using our perinatal database (1990-2008). Perinatal outcomes among women with chronic hypertension (n = 1032), superimposed preeclampsia (n = 489), and preeclampsia (n = 4217) were compared with outcomes of control subjects (n = 57,103). Outcomes among women with superimposed preeclampsia were also compared with outcomes of women with preeclampsia. Multivariable analysis was used to control for confounders. Results: Rates of small-for-gestational age, abruption, stillbirth, and eclampsia were not significantly different with superimposed preeclampsia compared with preeclampsia. Delivery at <34 weeks' gestation (17.3% vs 8.7%; P < .001), cesarean delivery (46.2% vs 36.3%; P < .001), and neonatal intensive care unit admission (16.3% vs 11.4%; P < .002) were significantly higher among women with superimposed preeclampsia. These risks persisted after we controlled for confounders. Conclusion: Women with superimposed preeclampsia have higher risks of intervention-related events compared with those with preeclampsia.

Original languageEnglish
Pages (from-to)508.e1-508.e7
JournalAmerican journal of obstetrics and gynecology
Issue number6
StatePublished - Jun 2011


  • adverse perinatal outcome
  • chronic hypertension
  • preeclampsia
  • superimposed preeclampsia


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