TY - JOUR
T1 - Perilesional edema in radiation necrosis reflects axonal degeneration
AU - Perez-Torres, Carlos J.
AU - Yuan, Liya
AU - Schmidt, Robert E.
AU - Rich, Keith M.
AU - Ackerman, Joseph J.H.
AU - Garbow, Joel R.
N1 - Publisher Copyright:
© Perez-Torres et al.
PY - 2015/1/31
Y1 - 2015/1/31
N2 - Background: Recently, we characterized a Gamma Knife® radiation necrosis mouse model with various magnetic resonance imaging (MRI) protocols to identify biomarkers useful in differentiation from tumors. Though the irradiation was focal to one hemisphere, a contralateral injury was observed that appeared to be localized in the white matter only. Interestingly, this injury was identifiable in T2-weighted images, apparent diffusion coefficient (ADC), and magnetization transfer ratio (MTR) maps, but not on post-contrast T1-weighted images. This observation of edema independent of vascular changes is akin to the perilesional edema seen in clinical radiation necrosis. Findings: The pathology underlying the observed white-matter MRI changes was explored by performing immunohistochemistry for healthy axons and myelin. The presence of both healthy axons and myelin was reduced in the contralateral white-matter lesion. Conclusions: Based on our immunohistochemical findings, the contralateral white-matter injury is most likely due to axonal degeneration.
AB - Background: Recently, we characterized a Gamma Knife® radiation necrosis mouse model with various magnetic resonance imaging (MRI) protocols to identify biomarkers useful in differentiation from tumors. Though the irradiation was focal to one hemisphere, a contralateral injury was observed that appeared to be localized in the white matter only. Interestingly, this injury was identifiable in T2-weighted images, apparent diffusion coefficient (ADC), and magnetization transfer ratio (MTR) maps, but not on post-contrast T1-weighted images. This observation of edema independent of vascular changes is akin to the perilesional edema seen in clinical radiation necrosis. Findings: The pathology underlying the observed white-matter MRI changes was explored by performing immunohistochemistry for healthy axons and myelin. The presence of both healthy axons and myelin was reduced in the contralateral white-matter lesion. Conclusions: Based on our immunohistochemical findings, the contralateral white-matter injury is most likely due to axonal degeneration.
KW - Axonal degeneration
KW - Radiation necrosis
KW - White matter injury
UR - http://www.scopus.com/inward/record.url?scp=84924255394&partnerID=8YFLogxK
U2 - 10.1186/s13014-015-0335-6
DO - 10.1186/s13014-015-0335-6
M3 - Article
C2 - 25636531
AN - SCOPUS:84924255394
VL - 10
JO - Radiation oncology (London, England)
JF - Radiation oncology (London, England)
SN - 1748-717X
IS - 1
M1 - 33
ER -