TY - JOUR
T1 - Peri-gestational risk factors for pediatric brain tumors in Neurofibromatosis Type 1
AU - Johnson, Kimberly J.
AU - Zoellner, Nancy L.
AU - Gutmann, David H.
N1 - Publisher Copyright:
© 2016 Elsevier Ltd.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Background: Individuals with Neurofibromatosis Type 1 (NF1) are strongly predisposed to developing pediatric brain tumors (PBTs), especially optic pathway gliomas (OPGs). Although developmental factors have been implicated in the origins of PBTs in both human and animal studies, associations between early-life factors and PBTs have not been evaluated in individuals with NF1. Our objective was to evaluate associations between peri-gestational characteristics and PBTs in this population. Methods: We conducted a cross-sectional study, ascertaining questionnaire and medical record data for 606 individuals <18 years old who enrolled in the NF1 Patient Registry Initiative (NPRI) from 6/9/2011-6/29/2015. One hundred eighty-four individuals had reported PBT diagnoses, including 65 who were identified with OPG diagnoses. Cox proportional hazards regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between PBT and OPG diagnoses and peri-gestational characteristics (prematurity, birth weight, parental age, plurality, family history of NF1, assisted reproductive technology, maternal vitamin supplementation, and parental smoking). Results: We observed no significant associations between any of the assessed characteristics and PBTs overall or OPGs with the exception of birth weight. After controlling for potential confounding variables, we observed a significant positive association between birth weight quartile and OPGs with a HR of 3.32 (95% CI 1.39-7.94) for the fourth (≥3915.5 g) compared to the first (≤3020 g) quartile (p for trend = 0.001). Conclusions: Consistent with results for PBTs in the general population, these results suggest that higher birth weights increase OPG risk in individuals with NF1.
AB - Background: Individuals with Neurofibromatosis Type 1 (NF1) are strongly predisposed to developing pediatric brain tumors (PBTs), especially optic pathway gliomas (OPGs). Although developmental factors have been implicated in the origins of PBTs in both human and animal studies, associations between early-life factors and PBTs have not been evaluated in individuals with NF1. Our objective was to evaluate associations between peri-gestational characteristics and PBTs in this population. Methods: We conducted a cross-sectional study, ascertaining questionnaire and medical record data for 606 individuals <18 years old who enrolled in the NF1 Patient Registry Initiative (NPRI) from 6/9/2011-6/29/2015. One hundred eighty-four individuals had reported PBT diagnoses, including 65 who were identified with OPG diagnoses. Cox proportional hazards regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between PBT and OPG diagnoses and peri-gestational characteristics (prematurity, birth weight, parental age, plurality, family history of NF1, assisted reproductive technology, maternal vitamin supplementation, and parental smoking). Results: We observed no significant associations between any of the assessed characteristics and PBTs overall or OPGs with the exception of birth weight. After controlling for potential confounding variables, we observed a significant positive association between birth weight quartile and OPGs with a HR of 3.32 (95% CI 1.39-7.94) for the fourth (≥3915.5 g) compared to the first (≤3020 g) quartile (p for trend = 0.001). Conclusions: Consistent with results for PBTs in the general population, these results suggest that higher birth weights increase OPG risk in individuals with NF1.
KW - Birth weight
KW - Brain neoplasms
KW - Glioma
KW - Neurofibromatosis 1
UR - http://www.scopus.com/inward/record.url?scp=84961627304&partnerID=8YFLogxK
U2 - 10.1016/j.canep.2016.03.005
DO - 10.1016/j.canep.2016.03.005
M3 - Article
C2 - 27018750
AN - SCOPUS:84961627304
SN - 1877-7821
VL - 42
SP - 53
EP - 59
JO - Cancer Epidemiology
JF - Cancer Epidemiology
ER -