TY - JOUR
T1 - Performance of two prognostic scores that incorporate genetic information to predict long-term outcomes following resection of colorectal cancer liver metastases
T2 - An external validation of the MD Anderson and JHH-MSK scores
AU - Sasaki, Kazunari
AU - Gagnière, Johan
AU - Dupré, Aurélien
AU - Ardiles, Victoria
AU - O'Connor, Juan Manuel
AU - Wang, Jaeyun
AU - Moro, Amika
AU - Morioka, Daisuke
AU - Buettner, Stefan
AU - Gau, Laurence
AU - Ribeiro, Mathieu
AU - Wagner, Doris
AU - Andreatos, Nikolaos
AU - Løes, Inger Marie
AU - Fitschek, Fabian
AU - Kaczirek, Klaus
AU - Lønning, Per Eystein
AU - Kornprat, Peter
AU - Poultsides, George
AU - Kamphues, Carsten
AU - Imai, Katsunori
AU - Baba, Hideo
AU - Endo, Itaru
AU - Kwon, Choon Hyuck David
AU - Aucejo, Federico N.
AU - de Santibañes, Eduardo
AU - Kreis, Martin E.
AU - Margonis, Georgios Antonios
N1 - Publisher Copyright:
© 2021 Japanese Society of Hepato-Biliary-Pancreatic Surgery.
PY - 2021/7
Y1 - 2021/7
N2 - Introduction: Two novel clinical risk scores (CRS) that incorporate KRAS mutation status were developed: modified CRS (mCRS) and GAME score. However, they have not been tested in large national and international cohorts. The aim of this study was to validate the prognostic discrimination utility and determine the clinical usefulness of the two novel CRS. Methods: Patients undergoing hepatectomy for CRLM (2000-2018) in 10 centers were included. The discriminatory abilities of mCRS, GAME, and Fong CRS were evaluated using Harrell's C-index and Akaike's Information Criterion. Results: In the entire cohort, the C-index of the GAME score (0.61) was significantly higher than those of Fong score (0.57) and mCRS (0.54), while the C-Index of mCRS was significantly lower than that of Fong score. When we compared the models in the various geographical regions, the C-index of GAME score was significantly higher than that of mCRS in North America, Europe, and South America. The AIC of Fong score, mCRS, and GAME score were 14 405, 14 447, and 14 319, respectively. Conclusion: In conclusion, using the largest and most heterogenous population of CRLM patients with known KRAS status, this independent, external validation demonstrated that the GAME score outperforms both the traditional Fong score and mCRS.
AB - Introduction: Two novel clinical risk scores (CRS) that incorporate KRAS mutation status were developed: modified CRS (mCRS) and GAME score. However, they have not been tested in large national and international cohorts. The aim of this study was to validate the prognostic discrimination utility and determine the clinical usefulness of the two novel CRS. Methods: Patients undergoing hepatectomy for CRLM (2000-2018) in 10 centers were included. The discriminatory abilities of mCRS, GAME, and Fong CRS were evaluated using Harrell's C-index and Akaike's Information Criterion. Results: In the entire cohort, the C-index of the GAME score (0.61) was significantly higher than those of Fong score (0.57) and mCRS (0.54), while the C-Index of mCRS was significantly lower than that of Fong score. When we compared the models in the various geographical regions, the C-index of GAME score was significantly higher than that of mCRS in North America, Europe, and South America. The AIC of Fong score, mCRS, and GAME score were 14 405, 14 447, and 14 319, respectively. Conclusion: In conclusion, using the largest and most heterogenous population of CRLM patients with known KRAS status, this independent, external validation demonstrated that the GAME score outperforms both the traditional Fong score and mCRS.
KW - KRAS
KW - clinical risk score
KW - colorectal liver metastases
KW - hepatectomy
KW - long-term outcome
UR - http://www.scopus.com/inward/record.url?scp=85104689918&partnerID=8YFLogxK
U2 - 10.1002/jhbp.963
DO - 10.1002/jhbp.963
M3 - Article
C2 - 33797866
AN - SCOPUS:85104689918
SN - 1868-6974
VL - 28
SP - 581
EP - 592
JO - Journal of Hepato-Biliary-Pancreatic Sciences
JF - Journal of Hepato-Biliary-Pancreatic Sciences
IS - 7
ER -