Performance of the xTAG® gastrointestinal pathogen panel, a multiplex molecular assay for simultaneous detection of bacterial, viral, and parasitic causes of infectious gastroenteritis

Eric C. Claas, Carey Ann D. Burnham, Tony Mazzulli, Kate Templeton, Francois Topin

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

The xTAG® Gastrointestinal Pathogen Panel (GPP) is a multiplexed molecular test for 15 gastrointestinal pathogens. The sensitivity and specificity of this test were assessed in 901 stool specimens collected from pediatric and adult patients at four clinical sites. A combination of conventional and molecular methods was used as comparator. Sensitivity could be determined for 12 of 15 pathogens and was 94.3% overall. The specificity across all 15 targets was 98.5%. Testing for the pathogen identified was not requested by the physician in 65% of specimens. The simultaneous detection of these 15 pathogens can provide physicians with a more comprehensive assessment of the etiology of diarrheal disease.

Original languageEnglish
Pages (from-to)1041-1045
Number of pages5
JournalJournal of Microbiology and Biotechnology
Volume23
Issue number7
DOIs
StatePublished - Jul 31 2013

Keywords

  • Gastroenteritis
  • Infectious diarrhea
  • Luminex
  • Multiplex
  • xTAG GPP

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