Performance evaluation of the microPET® - FOCUS-F120

Richard Laforest, Desmond Longford, Stefan Siegel, Danny F. Newport, Jeffrey Yap

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

microPET®-Focus-F120 is the latest model of dedicated small animal PET scanners from CTI-Concorde Microsystems LLC, (Knoxville, TN). This scanner, based on the geometry of the microPET-R4, takes advantage of several detector modifications to the coincidence processing electronics that improve the image resolution, sensitivity, and counting rate performance as compared to the predecessor models. This work evaluates the performance of the Focus-F120 system and shows its improvement over the earlier models. In particular, the spatial resolution is shown to improve from 2.32 to 1.69 mm at 5 mm radial distance and the peak absolute sensitivity increases from 4.1% to 7.1% compared to the microPET-R4. The counting rate capability, expressed in noise equivalent counting rate (NEC-1R), was shown to peak at over 800 kcps at 88 MBq for both systems using a mouse phantom. For this small phantom, the NECR counting rate is limited by the data transmission bandwidth between the scanner and the acquisition console. The rat-like phantom showed peak NEC-1R value at 300 kcps at 140 MBq. Evaluation of image quality and quantitation accuracy was also performed using specially designed phantoms and animal experiments.

Original languageEnglish
Pages (from-to)42-49
Number of pages8
JournalIEEE Transactions on Nuclear Science
Volume54
Issue number1
DOIs
StatePublished - Feb 2007

Keywords

  • NEC
  • Performance evaluation
  • Scatter fraction
  • Sensitivity
  • Small animal PET
  • Spatial resolution

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