TY - JOUR
T1 - Performance and Predictors of Migration of Partially and Fully Covered Esophageal Self-Expanding Metal Stents for Malignant Dysphagia
AU - Das, Koushik K.
AU - Hasak, Stephen
AU - Elhanafi, Sherif
AU - Visrodia, Kavel H.
AU - Ginsberg, Gregory G.
AU - Ahmad, Nuzhat A.
AU - Hollander, Thomas
AU - Lang, Gabriel
AU - Kushnir, Vladimir M.
AU - Mullady, Daniel K.
AU - Abu Dayyeh, Barham K.
AU - Buttar, Navtej S.
AU - Wong Kee Song, Louis Michel
AU - Kochman, Michael L.
AU - Chandrasekhara, Vinay
N1 - Funding Information:
The authors thank Jeffrey Elsner and Michael Ansstas for their work in the preparation of the clinical databases for this project. KKD, VC - Conceptualization, Data Curation, Formal Analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing - original draft, Writing - reviewing & editing, SH, SE - Data Curation, Formal Analysis, Validation, Writing - original drat, Writing - Reviewing and editing, KV, GG, NA, GL, VK, DM, ABD, NB, LWKS, MK - Data Curation, Formal Analysis, Writing - Reviewing and editing
Publisher Copyright:
© 2021 AGA Institute
PY - 2021/12
Y1 - 2021/12
N2 - Background & Aims: Self-expanding metal stents (SEMS) are routinely used to palliate malignant dysphagia. However esophageal SEMS can migrate or obstruct due to epithelial hyperplasia. The aim of this study was to evaluate the rates and factors predicting migration and obstruction, and the nutritional outcomes in partially covered (pc) vs. fully covered (fc) SEMS vs. fcSEMS with antimigration fins (AF) placed for malignant dysphagia. Methods: A retrospective review of consecutive patients undergoing SEMS placement for malignant dysphagia at three academic medical centers. Results: Among 357 patients, there were 55 (15.4%) stent migrations, 45 (12.6%) obstructions from epithelial hyperplasia, and 20 (5.6%) food impactions. Median overall survival was 79 days (IQR 41,199). The percent weight change/change in albumin at 30 and 60 days after SEMS placement were -2.24%/-0.544 g/dL and -2.98%/-0.55 g/dL, respectively. Stent migration occurred significantly more often with fcSEMS than pcSEMS (25.3% vs 10.9%; P <.003), but there was no difference when either group was compared to fcSEMS-AF (19.3%). The overall rate of epithelial hyperplasia resulting in stent obstruction was low (12.6%) and not different between stent types. Factors associated with increased risk of SEMS migration on multivariable logistic regression included stricture traversability with a diagnostic endoscope (OR, 2.37; 95% CI, 1.29-4.35) and use of fcSEMS (OR, 2.56; 1.31-5.00) or fcSEMS-AF (OR, 2.30, 1.03-5.14). Conclusions: Traversability of a malignant esophageal stenosis predicts SEMS migration. In these patients with a limited overall survival, pcSEMS are associated with lower rates of stent migration and similar rates of obstruction compared to fcSEMS.
AB - Background & Aims: Self-expanding metal stents (SEMS) are routinely used to palliate malignant dysphagia. However esophageal SEMS can migrate or obstruct due to epithelial hyperplasia. The aim of this study was to evaluate the rates and factors predicting migration and obstruction, and the nutritional outcomes in partially covered (pc) vs. fully covered (fc) SEMS vs. fcSEMS with antimigration fins (AF) placed for malignant dysphagia. Methods: A retrospective review of consecutive patients undergoing SEMS placement for malignant dysphagia at three academic medical centers. Results: Among 357 patients, there were 55 (15.4%) stent migrations, 45 (12.6%) obstructions from epithelial hyperplasia, and 20 (5.6%) food impactions. Median overall survival was 79 days (IQR 41,199). The percent weight change/change in albumin at 30 and 60 days after SEMS placement were -2.24%/-0.544 g/dL and -2.98%/-0.55 g/dL, respectively. Stent migration occurred significantly more often with fcSEMS than pcSEMS (25.3% vs 10.9%; P <.003), but there was no difference when either group was compared to fcSEMS-AF (19.3%). The overall rate of epithelial hyperplasia resulting in stent obstruction was low (12.6%) and not different between stent types. Factors associated with increased risk of SEMS migration on multivariable logistic regression included stricture traversability with a diagnostic endoscope (OR, 2.37; 95% CI, 1.29-4.35) and use of fcSEMS (OR, 2.56; 1.31-5.00) or fcSEMS-AF (OR, 2.30, 1.03-5.14). Conclusions: Traversability of a malignant esophageal stenosis predicts SEMS migration. In these patients with a limited overall survival, pcSEMS are associated with lower rates of stent migration and similar rates of obstruction compared to fcSEMS.
KW - Esophageal Obstruction Palliation
KW - Esophageal Stent
KW - Stent Migration
KW - Traversability
UR - http://www.scopus.com/inward/record.url?scp=85107577339&partnerID=8YFLogxK
U2 - 10.1016/j.cgh.2020.09.010
DO - 10.1016/j.cgh.2020.09.010
M3 - Article
C2 - 32898705
AN - SCOPUS:85107577339
SN - 1542-3565
VL - 19
SP - 2656-2663.e2
JO - Clinical Gastroenterology and Hepatology
JF - Clinical Gastroenterology and Hepatology
IS - 12
ER -