TY - JOUR
T1 - Perfluorocarbon nanoparticles for molecular imaging and targeted therapeutics
AU - Hughes, Michael
AU - Caruthers, Shelton
AU - Tran, Trung
AU - Marsh, Jon
AU - Wallace, Kirk
AU - Cyrus, Tillman
AU - Partlow, Kathryn
AU - Scott, Michael
AU - Lijowski, Michal
AU - Neubauer, Anne
AU - Winter, Patrick
AU - Hu, Grace
AU - Zhang, Hyuing
AU - McCarthy, John
AU - Maurizi, Brian
AU - Allen, John
AU - Caradine, Cordellia
AU - Neumann, Robert
AU - Arbeit, Jeffrey
AU - Lanza, Gregory
AU - Wickline, Samuel
PY - 2008/3
Y1 - 2008/3
N2 - Molecular imaging is a novel tool that has allowed noninvasive diagnostic imaging to transition from gross anatomical description to identification of specific tissue epitopes and observation of biological processes at the cellular level. Until recently, this technique was confined to the field of nuclear imaging; however, advances in nanotechnology have extended this research to include magnetic resonance (MR) imaging, positron emission tomography (PET), single photon emission computed tomography (SPECT), and ultrasound (US), among others. The application of nanotechnology to MR, SPECT, and US molecular imaging has generated several candidate contrast agents. We discuss the application of one multimodality platform, a targeted perfluorocarbon nanoparticle. Our results show that it is useful for noninvasive detection with all three imaging modalities and may additionally be used for local drug delivery.
AB - Molecular imaging is a novel tool that has allowed noninvasive diagnostic imaging to transition from gross anatomical description to identification of specific tissue epitopes and observation of biological processes at the cellular level. Until recently, this technique was confined to the field of nuclear imaging; however, advances in nanotechnology have extended this research to include magnetic resonance (MR) imaging, positron emission tomography (PET), single photon emission computed tomography (SPECT), and ultrasound (US), among others. The application of nanotechnology to MR, SPECT, and US molecular imaging has generated several candidate contrast agents. We discuss the application of one multimodality platform, a targeted perfluorocarbon nanoparticle. Our results show that it is useful for noninvasive detection with all three imaging modalities and may additionally be used for local drug delivery.
KW - Contrast agent
KW - Multiplatform contrast agent
KW - Targeted contrast
KW - Tumor imaging
UR - http://www.scopus.com/inward/record.url?scp=55349124222&partnerID=8YFLogxK
U2 - 10.1109/JPROC.2007.913500
DO - 10.1109/JPROC.2007.913500
M3 - Article
AN - SCOPUS:55349124222
SN - 0018-9219
VL - 96
SP - 397
EP - 415
JO - Proceedings of the IEEE
JF - Proceedings of the IEEE
IS - 3
M1 - 4446657
ER -