TY - JOUR
T1 - Percutaneous Image-Guided Cryoablation of Musculoskeletal Metastases
T2 - Pain Palliation and Local Tumor Control
AU - Wallace, Adam N.
AU - McWilliams, Sebastian R.
AU - Connolly, Sarah E.
AU - Symanski, John S.
AU - Vaswani, Devin
AU - Tomasian, Anderanik
AU - Vyhmeister, Ross
AU - Lee, Ashley M.
AU - Madaelil, Thomas P.
AU - Hillen, Travis J.
AU - Jennings, Jack W.
N1 - Publisher Copyright:
© 2016 SIR
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Purpose To evaluate the safety and effectiveness of cryoablation of musculoskeletal metastases in terms of achieving pain palliation and local tumor control. Materials and Methods A retrospective review was performed of 92 musculoskeletal metastases in 56 patients treated with percutaneous image-guided cryoablation. Mean age of the cohort was 53.9 y ± 15.1, and cohort included 48% (27/56) men. Median tumor volume was 13.0 cm3 (range, 0.5–577.2 cm3). Indications for treatment included pain palliation (41%; 38/92), local tumor control (15%; 14/92), or both (43%; 40/92). Concurrent cementoplasty was performed after 28% (26/92) of treatments. Results In 78 tumors treated for pain palliation, median pain score before treatment was 8.0. Decreased median pain scores were reported 1 day (6.0; P < .001, n = 62), 1 week (5.0; P < .001, n = 70), 1 month (5.0; P < .001, n = 63), and 3 months (4.5; P = .01, n = 28) after treatment. The median pain score at 6-month follow-up was 7.5 (P = .33, n = 11). Radiographic local tumor control rates were 90% (37/41) at 3 months, 86% (32/37) at 6 months, and 79% (26/33) at 12 months after treatment. The procedural complication rate was 4.3% (4/92). The 3 major complications included 2 cases of hemothorax and 1 transient foot drop. Conclusions Cryoablation is an effective treatment for palliating painful musculoskeletal metastases and achieving local tumor control.
AB - Purpose To evaluate the safety and effectiveness of cryoablation of musculoskeletal metastases in terms of achieving pain palliation and local tumor control. Materials and Methods A retrospective review was performed of 92 musculoskeletal metastases in 56 patients treated with percutaneous image-guided cryoablation. Mean age of the cohort was 53.9 y ± 15.1, and cohort included 48% (27/56) men. Median tumor volume was 13.0 cm3 (range, 0.5–577.2 cm3). Indications for treatment included pain palliation (41%; 38/92), local tumor control (15%; 14/92), or both (43%; 40/92). Concurrent cementoplasty was performed after 28% (26/92) of treatments. Results In 78 tumors treated for pain palliation, median pain score before treatment was 8.0. Decreased median pain scores were reported 1 day (6.0; P < .001, n = 62), 1 week (5.0; P < .001, n = 70), 1 month (5.0; P < .001, n = 63), and 3 months (4.5; P = .01, n = 28) after treatment. The median pain score at 6-month follow-up was 7.5 (P = .33, n = 11). Radiographic local tumor control rates were 90% (37/41) at 3 months, 86% (32/37) at 6 months, and 79% (26/33) at 12 months after treatment. The procedural complication rate was 4.3% (4/92). The 3 major complications included 2 cases of hemothorax and 1 transient foot drop. Conclusions Cryoablation is an effective treatment for palliating painful musculoskeletal metastases and achieving local tumor control.
UR - http://www.scopus.com/inward/record.url?scp=84991211249&partnerID=8YFLogxK
U2 - 10.1016/j.jvir.2016.07.026
DO - 10.1016/j.jvir.2016.07.026
M3 - Article
C2 - 27745968
AN - SCOPUS:84991211249
SN - 1051-0443
VL - 27
SP - 1788
EP - 1796
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
IS - 12
ER -