Percutaneous delivery of a heparin-impregnated collagen stent-graft in a porcine model of atherosclerotic disease

Scott C. Goodwin, Hyo Chun Yoon, Gordon C.H. Wong, Sheila M. Bonilla, Suresh Vedantham, Lokesh C. Arora

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

RATIONALE AND OBJECTIVES. To develop collagen stent-grafts impregnated with heparin to improve the biocompatibility of endovascular stents and to design a percutaneous delivery system for graft deployment in a swine model. METHODS. Heparin-impregnated collagen stent-grafts were deployed, and follow- up angiograms were obtained every 15 minutes for 90 minutes to assess acute thromboses and again at 2 and 4 weeks afterward to assess patency. If stenosis or occlusion was detected at the 2-week evaluation, guidewire passage across the lesion was attempted and angioplasty was performed. If stenosis or occlusion was present at the 4-week evaluation, only guidewire passage was attempted; thereafter, the animals were killed and the stent- grafts were harvested and reviewed by a vascular pathologist. RESULTS. Group A represents a feasibility study to optimize the deployment method applied in groups B and C. Fifteen of 17 stent-grafts were successfully deployed using this method. In group B, 89% of grafts were successfully deployed; 12% were patent at 2 weeks and none at 4 weeks. In group C, a 10-minute inflation time was added to the deployment procedure; 88% of grafts were successfully deployed and 28% were patent at 2 weeks and 14% at 4 weeks. Extensive luminal thrombosis and myointimal hyperplasia were present in every case. CONCLUSIONS. A method was developed for percutaneous implantation of collagen stent-grafts into peripheral vessels. The heparin-impregnated grafts did not prevent vessel restenosis. Modification of the graft-processing technique may improve patency.

Original languageEnglish
Pages (from-to)420-425
Number of pages6
JournalInvestigative Radiology
Volume35
Issue number7
DOIs
StatePublished - Jul 1 2000
Externally publishedYes

Keywords

  • Coating material
  • Heparin
  • Myointimal hyperplasia
  • Stent-graft
  • Thrombosis
  • Vein grafts

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