Peptidergic neurosecretory cells in insects: Organization and control by the bHLH protein DIMMED

Dongkook Park, Paul H. Taghert

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

This review considers evidence that defines a role for the transcription factor DIMMED in the regulation of insect neurosecretory cells. Genetic anatomical and molecular data all suggest DIMMED is a dedicated controller of the regulated secretory pathway. DIMM is normally expressed within diverse neuropeptide-expressing cells and appears highly correlated with a neurosecretory cell fate. Loss of DIMM is associated with deficits in display of neuropeptides and neuropeptide-associated enzymes. Gain of DIMM promotes such display in peptidergic cells and can confer such neurosecretory properties onto conventional neurons. We review models proposed to explain how DIMMED regulates these essential cellular properties.

Original languageEnglish
Pages (from-to)2-7
Number of pages6
JournalGeneral and Comparative Endocrinology
Volume162
Issue number1
DOIs
StatePublished - May 15 2009

Keywords

  • Drosophila
  • Neurosecretory neuron
  • Regulated secretory pathway
  • bHLH

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