Peptidergic neurosecretory cells in insects: Organization and control by the bHLH protein DIMMED

Dongkook Park; Paul H. Taghert

doi:10.1016/j.ygcen.2008.12.012

Peptidergic neurosecretory cells in insects: Organization and control by the bHLH protein DIMMED

Dongkook Park, Paul H. Taghert

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

This review considers evidence that defines a role for the transcription factor DIMMED in the regulation of insect neurosecretory cells. Genetic anatomical and molecular data all suggest DIMMED is a dedicated controller of the regulated secretory pathway. DIMM is normally expressed within diverse neuropeptide-expressing cells and appears highly correlated with a neurosecretory cell fate. Loss of DIMM is associated with deficits in display of neuropeptides and neuropeptide-associated enzymes. Gain of DIMM promotes such display in peptidergic cells and can confer such neurosecretory properties onto conventional neurons. We review models proposed to explain how DIMMED regulates these essential cellular properties.

Original language	English
Pages (from-to)	2-7
Number of pages	6
Journal	General and Comparative Endocrinology
Volume	162
Issue number	1
DOIs	https://doi.org/10.1016/j.ygcen.2008.12.012
State	Published - May 15 2009

Keywords

Drosophila
Neurosecretory neuron
Regulated secretory pathway
bHLH

Access to Document

10.1016/j.ygcen.2008.12.012

Cite this

@article{a6ac8922f05c4008b4419f632844944d,

title = "Peptidergic neurosecretory cells in insects: Organization and control by the bHLH protein DIMMED",

abstract = "This review considers evidence that defines a role for the transcription factor DIMMED in the regulation of insect neurosecretory cells. Genetic anatomical and molecular data all suggest DIMMED is a dedicated controller of the regulated secretory pathway. DIMM is normally expressed within diverse neuropeptide-expressing cells and appears highly correlated with a neurosecretory cell fate. Loss of DIMM is associated with deficits in display of neuropeptides and neuropeptide-associated enzymes. Gain of DIMM promotes such display in peptidergic cells and can confer such neurosecretory properties onto conventional neurons. We review models proposed to explain how DIMMED regulates these essential cellular properties.",

keywords = "Drosophila, Neurosecretory neuron, Regulated secretory pathway, bHLH",

author = "Dongkook Park and Taghert, {Paul H.}",

note = "Funding Information: We thank Tarik Hadzic for comments on a draft of this review. Work in the laboratory is supported by NIH Grants NS21749, MH067122, and GM85788, and by the Imaging Core Facility of the P30 NIH Neuroscience Blueprint Core Grant (#NS057105) to Washington University.",

year = "2009",

month = may,

day = "15",

doi = "10.1016/j.ygcen.2008.12.012",

language = "English",

volume = "162",

pages = "2--7",

journal = "General and Comparative Endocrinology",

issn = "0016-6480",

number = "1",

}

TY - JOUR

T1 - Peptidergic neurosecretory cells in insects

T2 - Organization and control by the bHLH protein DIMMED

AU - Park, Dongkook

AU - Taghert, Paul H.

N1 - Funding Information: We thank Tarik Hadzic for comments on a draft of this review. Work in the laboratory is supported by NIH Grants NS21749, MH067122, and GM85788, and by the Imaging Core Facility of the P30 NIH Neuroscience Blueprint Core Grant (#NS057105) to Washington University.

PY - 2009/5/15

Y1 - 2009/5/15

N2 - This review considers evidence that defines a role for the transcription factor DIMMED in the regulation of insect neurosecretory cells. Genetic anatomical and molecular data all suggest DIMMED is a dedicated controller of the regulated secretory pathway. DIMM is normally expressed within diverse neuropeptide-expressing cells and appears highly correlated with a neurosecretory cell fate. Loss of DIMM is associated with deficits in display of neuropeptides and neuropeptide-associated enzymes. Gain of DIMM promotes such display in peptidergic cells and can confer such neurosecretory properties onto conventional neurons. We review models proposed to explain how DIMMED regulates these essential cellular properties.

AB - This review considers evidence that defines a role for the transcription factor DIMMED in the regulation of insect neurosecretory cells. Genetic anatomical and molecular data all suggest DIMMED is a dedicated controller of the regulated secretory pathway. DIMM is normally expressed within diverse neuropeptide-expressing cells and appears highly correlated with a neurosecretory cell fate. Loss of DIMM is associated with deficits in display of neuropeptides and neuropeptide-associated enzymes. Gain of DIMM promotes such display in peptidergic cells and can confer such neurosecretory properties onto conventional neurons. We review models proposed to explain how DIMMED regulates these essential cellular properties.

KW - Drosophila

KW - Neurosecretory neuron

KW - Regulated secretory pathway

KW - bHLH

UR - http://www.scopus.com/inward/record.url?scp=65049085590&partnerID=8YFLogxK

U2 - 10.1016/j.ygcen.2008.12.012

DO - 10.1016/j.ygcen.2008.12.012

M3 - Article

C2 - 19135054

AN - SCOPUS:65049085590

VL - 162

SP - 2

EP - 7

JO - General and Comparative Endocrinology

JF - General and Comparative Endocrinology

SN - 0016-6480

IS - 1

ER -

Peptidergic neurosecretory cells in insects: Organization and control by the bHLH protein DIMMED

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this