Peptide Neuromodulation in Invertebrate Model Systems

Paul H. Taghert, Michael N. Nitabach

Research output: Contribution to journalReview articlepeer-review

170 Scopus citations


Neuropeptides modulate neural circuits controlling adaptive animal behaviors and physiological processes, such as feeding/metabolism, reproductive behaviors, circadian rhythms, central pattern generation, and sensorimotor integration. Invertebrate model systems have enabled detailed experimental analysis using combined genetic, behavioral, and physiological approaches. Here we review selected examples of neuropeptide modulation in crustaceans, mollusks, insects, and nematodes, with a particular emphasis on the genetic model organisms Drosophila melanogaster and Caenorhabditis elegans, where remarkable progress has been made. On the basis of this survey, we provide several integrating conceptual principles for understanding how neuropeptides modulate circuit function, and also propose that continued progress in this area requires increased emphasis on the development of richer, more sophisticated behavioral paradigms.

Original languageEnglish
Pages (from-to)82-97
Number of pages16
Issue number1
StatePublished - Oct 4 2012


Dive into the research topics of 'Peptide Neuromodulation in Invertebrate Model Systems'. Together they form a unique fingerprint.

Cite this