Penetration depth in tissue-mimicking phantoms from hyperspectral imaging in SWIR in transmission and reflection geometry

Hairong Zhang, Daniel Salo, David M. Kim, Mikhail Y. Berezin

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

We explored the depth penetration in tissue-mimicking intralipid-based phantoms in SWIR (800-1650 nm) using a hyperspectral imaging system composed from a 2D CCD camera coupled to a microscope. Hyperspectral images in transmission and reflection geometries were collected with a spectral resolution of 5.27 nm and a total acquisition time of 3 minutes or less that minimized artifacts from sample drying. Michelson spatial contrast was used as a metric to evaluate light penetration. Results from both transmission and reflection geometries consistently revealed the highest spatial contrast in the wavelength range of 1300 to 1350 nm.

Original languageEnglish
Title of host publicationOptical Biopsy XIV
Subtitle of host publicationToward Real-Time Spectroscopic Imaging and Diagnosis
EditorsStavros G. Demos, Robert R. Alfano
PublisherSPIE
ISBN (Electronic)9781628419375
DOIs
StatePublished - Jan 1 2016
EventOptical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis - San Francisco, United States
Duration: Feb 15 2016Feb 17 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9703
ISSN (Print)1605-7422

Conference

ConferenceOptical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis
Country/TerritoryUnited States
CitySan Francisco
Period02/15/1602/17/16

Keywords

  • Deep tissue imaging
  • ExNIR
  • Hyperspectral imaging (HSI)
  • Optical imaging
  • SWIR
  • Spatial contrast
  • Tissue phantom

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