Penetration and activation of brain endothelium by Salmonella enterica serovar typhimurium

Nina M. Van Sorge, Patricia A. Zialcita, Sara H. Browne, Darin Quach, Donald G. Guiney, Kelly S. Doran

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Salmonella meningitis is a serious disease of the central nervous system, common particularly in Africa. Here, we show that Salmonella enterica serovar Typhimurium is able to adhere, invade, and penetrate human brain microvascular endothelial cells (hBMECs), the single-cell layer constituting the blood-brain barrier (BBB). Cellular invasion was dependent on host actin cytoskeleton rearrangements, while expression of a functional type III secretion system was not essential. In addition, Salmonella infection activated a proinflammatory immune response targeting neutrophil signaling and recruitment. Salmonella invasion and immune activation may represent a crucial step in the penetration of the BBB and development of Salmonella meningitis.

Original languageEnglish
Pages (from-to)401-405
Number of pages5
JournalJournal of Infectious Diseases
Issue number3
StatePublished - Feb 1 2011


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