TY - JOUR
T1 - Pediatric Suprasellar Tumors
T2 - Unveiling the Mysteries of Craniopharyngioma and Germ Cell Tumors—Insights From Diagnosis to Advanced Therapeutics
AU - Shatara, Margaret
AU - Abdelbaki, Mohamed S.
N1 - Publisher Copyright:
© 2024 Elsevier Inc.
PY - 2025/1
Y1 - 2025/1
N2 - Background: Pediatric suprasellar tumors represent a unique and intricate challenge in the landscape of pediatric neuro-oncology. Methods: We conducted an in-depth literature review, focusing on large clinical trials and major publications in pediatric suprasellar tumors, particularly craniopharyngiomas and germ cell tumors, to provide a comprehensive perspective on the challenges in the diagnosis, treatment, and molecular aspects of these tumors. Results: Nestled within the critical confines of the suprasellar region, these tumors manifest against the backdrop of crucial growth and developmental processes. The suprasellar region, housing the pituitary gland and surrounding structures, plays a pivotal role in orchestrating hormonal regulation and growth. The emergence of tumors within this delicate terrain introduces a complex array of challenges, encompassing neurological, endocrinological, and developmental dimensions from damage to the hypothalamic-pituitary axis. Conclusions: This article provides a thorough exploration of pediatric craniopharyngiomas and germ cell tumors, elucidating their clinical presentations, treatment modalities, and outcomes. The focused analysis aims to deepen our understanding of these tumors by offering insights for refined clinical management and improved patient outcomes.
AB - Background: Pediatric suprasellar tumors represent a unique and intricate challenge in the landscape of pediatric neuro-oncology. Methods: We conducted an in-depth literature review, focusing on large clinical trials and major publications in pediatric suprasellar tumors, particularly craniopharyngiomas and germ cell tumors, to provide a comprehensive perspective on the challenges in the diagnosis, treatment, and molecular aspects of these tumors. Results: Nestled within the critical confines of the suprasellar region, these tumors manifest against the backdrop of crucial growth and developmental processes. The suprasellar region, housing the pituitary gland and surrounding structures, plays a pivotal role in orchestrating hormonal regulation and growth. The emergence of tumors within this delicate terrain introduces a complex array of challenges, encompassing neurological, endocrinological, and developmental dimensions from damage to the hypothalamic-pituitary axis. Conclusions: This article provides a thorough exploration of pediatric craniopharyngiomas and germ cell tumors, elucidating their clinical presentations, treatment modalities, and outcomes. The focused analysis aims to deepen our understanding of these tumors by offering insights for refined clinical management and improved patient outcomes.
KW - ACP
KW - GCT
KW - MAPK/ERK pathway
KW - Molecular landscape
KW - Programmed cell death pathway
KW - Suprasellar tumors
UR - http://www.scopus.com/inward/record.url?scp=85209241340&partnerID=8YFLogxK
U2 - 10.1016/j.pediatrneurol.2024.10.016
DO - 10.1016/j.pediatrneurol.2024.10.016
M3 - Article
C2 - 39561686
AN - SCOPUS:85209241340
SN - 0887-8994
VL - 162
SP - 55
EP - 68
JO - Pediatric Neurology
JF - Pediatric Neurology
ER -