TY - JOUR
T1 - Pediatric lung transplantation
T2 - Radiographic-histopathologic correlation
AU - Medina, L. S.
AU - Siegel, M. J.
AU - Bejarano, P. A.
AU - Glazer, H. S.
AU - Anderson, D. J.
AU - Mallory, G. B.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - Chest radiographic and histopathologic findings were retrospectively reviewed to determine the spectrum of findings in 16 children who underwent a total of 19 lung transplantations. Radiographs were evaluated for air-space disease, interstitial disease, Kerley B lines, pleural fluid, and cardiac size, and the interval from transplantation to the onset of complications was determined. Radiographic findings were correlated with 62 histopathologic diagnoses obtained from 51 transbronchial and open lung biopsy specimens. The final histopathologic diagnoses were acute rejection (n = 19), chronic rejection (n = 8), infection (n = 11), lymphoproliferative disorder (n = 4), and nonspecific (n = 20). The radiographic patterns of the complications were not significantly different. Seventy-nine percent (15 of 19) of episodes of acute rejection and 64% (seven of 11) of episodes of infection occurred within 5 weeks of transplantation, while 63% (five of eight) of the episodes of chronic rejection occurred after this period. Since chest radiographs are nonspecific, caution should be exercised in basing clinical decisions only on the radiographic pattern in the absence of corroborative clinical and histopathologic findings.
AB - Chest radiographic and histopathologic findings were retrospectively reviewed to determine the spectrum of findings in 16 children who underwent a total of 19 lung transplantations. Radiographs were evaluated for air-space disease, interstitial disease, Kerley B lines, pleural fluid, and cardiac size, and the interval from transplantation to the onset of complications was determined. Radiographic findings were correlated with 62 histopathologic diagnoses obtained from 51 transbronchial and open lung biopsy specimens. The final histopathologic diagnoses were acute rejection (n = 19), chronic rejection (n = 8), infection (n = 11), lymphoproliferative disorder (n = 4), and nonspecific (n = 20). The radiographic patterns of the complications were not significantly different. Seventy-nine percent (15 of 19) of episodes of acute rejection and 64% (seven of 11) of episodes of infection occurred within 5 weeks of transplantation, while 63% (five of eight) of the episodes of chronic rejection occurred after this period. Since chest radiographs are nonspecific, caution should be exercised in basing clinical decisions only on the radiographic pattern in the absence of corroborative clinical and histopathologic findings.
KW - Children, respiratory system
KW - Hypertension, pulmonary
KW - Lung, diseases
KW - Lung, fibrosis
KW - Lung, transplantation
KW - Pulmonary valve
UR - http://www.scopus.com/inward/record.url?scp=0027175121&partnerID=8YFLogxK
U2 - 10.1148/radiology.187.3.8497635
DO - 10.1148/radiology.187.3.8497635
M3 - Article
C2 - 8497635
AN - SCOPUS:0027175121
VL - 187
SP - 807
EP - 810
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 3
ER -