Pediatric gliomas as neurodevelopmental disorders

Suzanne J. Baker, David W. Ellison, David H. Gutmann

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Brain tumors represent the most common solid tumor of childhood, with gliomas comprising the largest fraction of these cancers. Several features distinguish them from their adult counterparts, including their natural history, causative genetic mutations, and brain locations. These unique properties suggest that the cellular and molecular etiologies that underlie their development and maintenance might be different from those that govern adult gliomagenesis and growth. In this review, we discuss the genetic basis for pediatric low-grade and high-grade glioma in the context of developmental neurobiology, and highlight the differences between histologically-similar tumors arising in children and adults. GLIA 2016;64:879-895 Main Points: Pediatric gliomas comprise a heterogeneous collection of glial neoplasms driven by different molecular events. Herein, we discuss the intersection between developmental neurobiology and pediatric neuro-oncology focusing on childhood glial neoplasms.

Original languageEnglish
Pages (from-to)879-895
Number of pages17
JournalGlia
Volume64
Issue number6
DOIs
StatePublished - Jun 1 2016

Keywords

  • DIPG
  • Diffuse astrocytoma
  • Glioblastoma
  • Pediatric glioma
  • Pilocytic astrocytoma

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