Pediatric acute kidney injury: Prevalence, impact and management challenges

Eileen Ciccia, Prasad Devarajan

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

The incidence of pediatric acute kidney injury (AKI) is increasing globally, as are the associated morbidities and mortality. A recent standardization of the definition of AKI has allowed for a more accurate assessment of the epidemiology of pediatric AKI. Recent advances in leveraging electronic medical health record systems have allowed for real-time risk stratification and prevention of pediatric AKI in the hospital setting. Newly developed and validated clinical scores have improved our ability to predict AKI and provide a rational context for biomarker utilization in hospitalized children. Novel non-invasive diagnostic and predictive biomarkers have been launched globally to improve our ability to diagnose and predict AKI and its adverse outcomes as well as recovery. This review summarizes the most current literature, focusing on the epidemiology, management, and early diagnostic strategies in pediatric AKI.

Original languageEnglish
Pages (from-to)77-84
Number of pages8
JournalInternational Journal of Nephrology and Renovascular Disease
Volume10
DOIs
StatePublished - Mar 29 2017

Keywords

  • Acute kidney injury
  • Acute renal failure
  • Biomarkers
  • Children
  • Epidemiology
  • Neutrophil gelatinase-associated lipocalin

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