TY - JOUR
T1 - Pearls & Oy-sters
T2 - MOG-AD Meningoencephalitis With Holocord Gray Matter Predominant Myelitis
AU - Farkas, Nathan Shmuel
AU - Zolno, Rachel
AU - Gaudioso, Cristina M.
AU - Mian, Ali Y.
AU - Mar, Soe
N1 - Publisher Copyright:
© American Academy of Neurology.
PY - 2023/10/10
Y1 - 2023/10/10
N2 - Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) has been implicated in a wide range of CNS encephalitis and myelitis presentations. We present a previously healthy 16-year-old girl who presented with acute onset headaches that rapidly progressed to encephalopathy, flaccid paraparesis, lower extremity hyperreflexia, and urinary retention. Serial MRI brain and total spine imaging demonstrated evolving diffuse supratentorial leptomeningeal enhancement and holocord gray matter restricted T2 bright lesion without enhancement. CSF was markedly inflammatory with MOG antibody positive >1:10,000. The patient improved after empiric steroids, plasma exchange, and IVIG.
AB - Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) has been implicated in a wide range of CNS encephalitis and myelitis presentations. We present a previously healthy 16-year-old girl who presented with acute onset headaches that rapidly progressed to encephalopathy, flaccid paraparesis, lower extremity hyperreflexia, and urinary retention. Serial MRI brain and total spine imaging demonstrated evolving diffuse supratentorial leptomeningeal enhancement and holocord gray matter restricted T2 bright lesion without enhancement. CSF was markedly inflammatory with MOG antibody positive >1:10,000. The patient improved after empiric steroids, plasma exchange, and IVIG.
UR - http://www.scopus.com/inward/record.url?scp=85173582227&partnerID=8YFLogxK
U2 - 10.1212/WNL.0000000000207637
DO - 10.1212/WNL.0000000000207637
M3 - Article
C2 - 37487743
AN - SCOPUS:85173582227
SN - 0028-3878
VL - 101
SP - E1577-E1580
JO - Neurology
JF - Neurology
IS - 15
ER -