Peanut allergy diagnosis: A 2020 practice parameter update, systematic review, and GRADE analysis

Matthew Greenhawt; Marcus Shaker; Julie Wang; John J. Oppenheimer; Scott Sicherer; Corinne Keet; Keri Swaggart; Matthew Rank; Jay M. Portnoy; Jonathan Bernstein; Derek K. Chu; Chitra Dinakar; David Golden; Carolyn Horner; David M. Lang; Eddy S. Lang; David A. Khan; Jay Lieberman; David Stukus; Dana Wallace

doi:10.1016/j.jaci.2020.07.031

Peanut allergy diagnosis: A 2020 practice parameter update, systematic review, and GRADE analysis

Matthew Greenhawt, Marcus Shaker, Julie Wang, John J. Oppenheimer, Scott Sicherer, Corinne Keet, Keri Swaggart, Matthew Rank, Jay M. Portnoy, Jonathan Bernstein, Derek K. Chu, Chitra Dinakar, David Golden, Carolyn Horner, David M. Lang, Eddy S. Lang, David A. Khan, Jay Lieberman, David Stukus, Dana Wallace

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77 Scopus citations

Abstract

Given the burden of disease and the consequences of a diagnosis of peanut allergy, it is important that peanut allergy be accurately diagnosed so that an appropriate treatment plan can be developed. However, a test that indicates there is peanut sensitization present (eg, a “positive” test) is not always associated with clinical reactivity. This practice parameter addresses the diagnosis of IgE-mediated peanut allergy, both in children and adults, as pertaining to 3 fundamental questions, and based on the systematic reviews and meta-analyses, makes recommendations for the clinician who is evaluating a patient for peanut allergy. These questions relate to when diagnostic tests should be completed, which diagnostic tests to utilize, and the utility (or lack thereof) of diagnostic testing to predict the severity of a future allergic reaction to peanut.

Original language	English
Pages (from-to)	1302-1334
Number of pages	33
Journal	Journal of Allergy and Clinical Immunology
Volume	146
Issue number	6
DOIs	https://doi.org/10.1016/j.jaci.2020.07.031
State	Published - Dec 2020

Keywords

Ara h 2
GRADE analysis
Peanut allergy
cost-effectiveness analysis
diagnosis
evidence to recommendation
likelihood ratio
meta-analysis
peanut components
practice parameter update
serologic IgE testing
skin prick testing
systematic review

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10.1016/j.jaci.2020.07.031

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Greenhawt, M., Shaker, M., Wang, J., Oppenheimer, J. J., Sicherer, S., Keet, C., Swaggart, K., Rank, M., Portnoy, J. M., Bernstein, J., Chu, D. K., Dinakar, C., Golden, D., Horner, C., Lang, D. M., Lang, E. S., Khan, D. A., Lieberman, J., Stukus, D., & Wallace, D. (2020). Peanut allergy diagnosis: A 2020 practice parameter update, systematic review, and GRADE analysis. Journal of Allergy and Clinical Immunology, 146(6), 1302-1334. https://doi.org/10.1016/j.jaci.2020.07.031

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title = "Peanut allergy diagnosis: A 2020 practice parameter update, systematic review, and GRADE analysis",

abstract = "Given the burden of disease and the consequences of a diagnosis of peanut allergy, it is important that peanut allergy be accurately diagnosed so that an appropriate treatment plan can be developed. However, a test that indicates there is peanut sensitization present (eg, a “positive” test) is not always associated with clinical reactivity. This practice parameter addresses the diagnosis of IgE-mediated peanut allergy, both in children and adults, as pertaining to 3 fundamental questions, and based on the systematic reviews and meta-analyses, makes recommendations for the clinician who is evaluating a patient for peanut allergy. These questions relate to when diagnostic tests should be completed, which diagnostic tests to utilize, and the utility (or lack thereof) of diagnostic testing to predict the severity of a future allergic reaction to peanut.",

keywords = "Ara h 2, GRADE analysis, Peanut allergy, cost-effectiveness analysis, diagnosis, evidence to recommendation, likelihood ratio, meta-analysis, peanut components, practice parameter update, serologic IgE testing, skin prick testing, systematic review",

author = "Matthew Greenhawt and Marcus Shaker and Julie Wang and Oppenheimer, {John J.} and Scott Sicherer and Corinne Keet and Keri Swaggart and Matthew Rank and Portnoy, {Jay M.} and Jonathan Bernstein and Chu, {Derek K.} and Chitra Dinakar and David Golden and Carolyn Horner and Lang, {David M.} and Lang, {Eddy S.} and Khan, {David A.} and Jay Lieberman and David Stukus and Dana Wallace",

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year = "2020",

month = dec,

doi = "10.1016/j.jaci.2020.07.031",

language = "English",

volume = "146",

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Greenhawt, M, Shaker, M, Wang, J, Oppenheimer, JJ, Sicherer, S, Keet, C, Swaggart, K, Rank, M, Portnoy, JM, Bernstein, J, Chu, DK, Dinakar, C, Golden, D, Horner, C, Lang, DM, Lang, ES, Khan, DA, Lieberman, J, Stukus, D & Wallace, D 2020, 'Peanut allergy diagnosis: A 2020 practice parameter update, systematic review, and GRADE analysis', Journal of Allergy and Clinical Immunology, vol. 146, no. 6, pp. 1302-1334. https://doi.org/10.1016/j.jaci.2020.07.031

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AU - Sicherer, Scott

AU - Keet, Corinne

AU - Swaggart, Keri

AU - Rank, Matthew

AU - Portnoy, Jay M.

AU - Bernstein, Jonathan

AU - Chu, Derek K.

AU - Dinakar, Chitra

AU - Golden, David

AU - Horner, Carolyn

AU - Lang, David M.

AU - Lang, Eddy S.

AU - Khan, David A.

AU - Lieberman, Jay

AU - Stukus, David

AU - Wallace, Dana

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KW - skin prick testing

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Peanut allergy diagnosis: A 2020 practice parameter update, systematic review, and GRADE analysis

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Keywords

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