PDL-1 blockade impedes T cell expansion and protective immunity primed by attenuated listeria monocytogenes

Jared H. Rowe, Tanner M. Johanns, James M. Ertelt, Sing Sing Way

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Infection with attenuated Listeria monocytogenes (Lm) is a robust in vivo model for examining how Ag-specific T cells are primed, and subsequent challenge with virulent Lm allows for the protective effects of T cell priming to be quantified. Herein, we investigated the role of programmed death Iigand 1 (PDL-1) in T cell priming and immunity conferred after primary infection with Lm AactA followed by virulent Lm challenge. In striking contrast to the inhibitory role of PDL-1 on T cell immunity in other infection models, marked reductions in the magnitude of T cell expansion and the kinetics of T cell proliferation were observed with PDL-1 blockade after primary Lm AactA infection. More importantly, PDL-1 blockade beginning before primary infection and maintained throughout the experiment resulted in delayed bacterial clearance and T cell expansion after secondary challenge with virulent Lm. These results indicate that for immunity to intracellular bacterial infection, PDL-1 plays an important stimulatory role for priming and expansion of protective T cells.

Original languageEnglish
Pages (from-to)7553-7557
Number of pages5
JournalJournal of Immunology
Volume180
Issue number11
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

Fingerprint Dive into the research topics of 'PDL-1 blockade impedes T cell expansion and protective immunity primed by attenuated listeria monocytogenes'. Together they form a unique fingerprint.

  • Cite this