PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway

Keyphrases

• Mitogen-activated Protein Kinase 100%
• Platelets 100%
• Thrombosis 100%
• Thromboxane 100%
• RAF1 100%
• PDK1 100%
• Phosphorylation 21%
• Platelet Activation 21%
• Genetic Ablation 15%
• Pulmonary Embolism 10%
• Upstream Kinases 10%
• Thrombus Formation 10%
• BX795 10%
• Knock-in Mouse Model 5%
• Phosphoinositide 3-kinase (PI3K) 5%
• Collagen 5%
• Adenosine Diphosphate 5%
• Epinephrine 5%
• Oncogene 5%
• Western Blot Analysis 5%
• Extracellular Signal-regulated Kinase 1/2 5%
• Pharmacological Inhibitors 5%
• Effector Cells 5%
• Thrombotic 5%
• Serine-threonine Kinase 5%
• Platelet Thrombosis 5%
• Cytosolic Phospholipase A2 (cPLA2) 5%
• In Vitro Inhibition 5%
• Induced Aggregation 5%
• Methylthiol 5%
• Functional Importance 5%
• ADP Receptors 5%
• Platelet Thrombus 5%
• Protease-activated Receptor 4 (PAR4) 5%
• Glycogen Synthase 5%
• Pathway Crosstalk 5%

Biochemistry, Genetics and Molecular Biology

• Mitogen-Activated Protein Kinase 100%
• Phosphoinositide-Dependent Kinase-1 100%
• Platelet 100%
• Thromboxane 100%
• Kinase 22%
• Phosphotransferase 22%
• Adenosine Diphosphate 22%
• Thrombocyte Activation 22%
• Genetic Ablation 16%
• Coagulation System 11%
• Mitogen-Activated Protein Kinase Kinase 11%
• Knockout Mouse 5%
• Phosphoinositide 3-Kinase 5%
• Epinephrine 5%
• Western Blot 5%
• Phospholipase A2 5%
• Proto Oncogene 5%
• Extracellular Signal-Regulated Kinases 5%
• Protease-Activated Receptor 5%
• Glycogen Synthase 5%
• Serine 5%
• Threonine 5%