PCR for the diagnosis of toxoplasmosis after hematopoietic stem cell transplantation

James S. Lewis, Hanna Khoury, Gregory A. Storch, John DiPersio

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Toxoplasma gondii is a ubiquitous pathogen that causes significant morbidity and mortality in immunocompromised patients. Although relatively uncommon, toxoplasmosis is increasingly recognized as a severe complication of hematopoletic stem cell transplantation. Timely and accurate diagnosis of this treatable infection is critical. PCR-based testing has become the preferred method for diagnosis, occasionally replacing tissue biopsy. This article reviews the clinical, diagnostic and therapeutic aspects of toxoplasmosis in the setting of hematopoletic stem cell transplantation and the current and future role of PCR-based testing for early detection and diagnosis.

Original languageEnglish
Pages (from-to)616-624
Number of pages9
JournalExpert Review of Molecular Diagnostics
Volume2
Issue number6
DOIs
StatePublished - Nov 1 2002

Keywords

  • Diagnosis
  • Hematopoietic stem cell transplantation
  • PCR
  • Toxoplasmosis

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