TY - JOUR
T1 - PCLO gene
T2 - Its role in vulnerability to major depressive disorder
AU - Minelli, Alessandra
AU - Scassellati, Catia
AU - Cloninger, Claude Robert
AU - Tessari, Elisabetta
AU - Bortolomasi, Marco
AU - Bonvicini, Cristian
AU - Giacopuzzi, Mario
AU - Frisoni, Giovanni Battista
AU - Gennarelli, Massimo
N1 - Funding Information:
Funding for this study was provided by Italian Ministry of Health (RC and RF2007 Conv. 42) and Regione Lombardia (ID: 17387 SAL-13). Italian Ministry of Health and Regione Lombardia had no further role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
Funding Information:
This research was supported by grants from the Italian Ministry of Health (RC and RF2007 Conv. 42) and Regione Lombardia (ID: 17387 SAL-13 ). We thank Luisa Boventi, Francesco Roversi, Federica Centin and Barbara Bertasi for laboratory support. Furthermore, the authors would like to express sincere gratitude to all volunteers that participated in the study.
PY - 2012/8
Y1 - 2012/8
N2 - Background: A recent genome-wide association study on Major Depressive Disorder (MDD) identified a specific association with a non-synonymous polymorphism (rs2522833) of a gene encoding the presynaptic protein piccolo (PCLO). A high percentage of patients who develop MDD have particular temperamental traits, such as passivity, pessimism, indecisiveness, and low self-esteem, which are related to the subsequent development of depression. The aims of this study were to perform a replicate case-control study and to conduct the first association study between the rs2522833 polymorphism and depression-related personality traits using the Temperament and Character Inventory (TCI) in a healthy subject sample. Methods: A total of 522 MDD patients and 375 healthy volunteers were enrolled in the study. Two hundred and forty-six controls agreed to fill out the TCI. Results: The results showed that rs2522833 CC homozygotes were more frequent among the depressed patients than in the controls (p < 0.01). The C allele distribution showed a trend in the same direction (p = 0.08). Among controls, we found that the C allele carriers were associated with personality traits increasing vulnerability to depression, including higher Harm Avoidance (HA) and lower in Novelty Seeking (NS). In particular, C allele carriers were more fearful (HA2) and fatigable (HA4), and less impulsive/more deliberate (NS2) and less extravagant/more frugal (NS3). Limitations: The absence of possible epistatic interaction effect. Conclusions: These results provide further support for the involvement of the PCLO gene in MDD and show that this effect may be mediated by influencing personality traits that increase the risk of major depression.
AB - Background: A recent genome-wide association study on Major Depressive Disorder (MDD) identified a specific association with a non-synonymous polymorphism (rs2522833) of a gene encoding the presynaptic protein piccolo (PCLO). A high percentage of patients who develop MDD have particular temperamental traits, such as passivity, pessimism, indecisiveness, and low self-esteem, which are related to the subsequent development of depression. The aims of this study were to perform a replicate case-control study and to conduct the first association study between the rs2522833 polymorphism and depression-related personality traits using the Temperament and Character Inventory (TCI) in a healthy subject sample. Methods: A total of 522 MDD patients and 375 healthy volunteers were enrolled in the study. Two hundred and forty-six controls agreed to fill out the TCI. Results: The results showed that rs2522833 CC homozygotes were more frequent among the depressed patients than in the controls (p < 0.01). The C allele distribution showed a trend in the same direction (p = 0.08). Among controls, we found that the C allele carriers were associated with personality traits increasing vulnerability to depression, including higher Harm Avoidance (HA) and lower in Novelty Seeking (NS). In particular, C allele carriers were more fearful (HA2) and fatigable (HA4), and less impulsive/more deliberate (NS2) and less extravagant/more frugal (NS3). Limitations: The absence of possible epistatic interaction effect. Conclusions: These results provide further support for the involvement of the PCLO gene in MDD and show that this effect may be mediated by influencing personality traits that increase the risk of major depression.
KW - Harm avoidance
KW - Major Depressive Disorder
KW - PCLO gene
KW - TCI
KW - rs2522833
UR - http://www.scopus.com/inward/record.url?scp=84862139697&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2012.01.028
DO - 10.1016/j.jad.2012.01.028
M3 - Article
C2 - 22386049
AN - SCOPUS:84862139697
SN - 0165-0327
VL - 139
SP - 250
EP - 255
JO - Journal of affective disorders
JF - Journal of affective disorders
IS - 3
ER -