TY - JOUR
T1 - PC Cell-Derived Growth Factor Expression in Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma
AU - Pan, Chong Xian
AU - Kinch, Michael S.
AU - Kiener, Peter A.
AU - Langermann, Solomon
AU - Serrero, Ginette
AU - Sun, Le
AU - Corvera, Joseph
AU - Sweeney, Christopher J.
AU - Li, Lang
AU - Zhang, Shaobo
AU - Baldridge, Lee Ann
AU - Jones, Timothy D.
AU - Koch, Michael O.
AU - Ulbright, Thomas M.
AU - Eble, John N.
AU - Cheng, Liang
PY - 2004/2/15
Y1 - 2004/2/15
N2 - Purpose: PCDGF (PC cell-derived growth factor), also called progranulin, is a Mr 88,000 glycoprotein precursor of granulin. It is a novel growth factor that stimulates cell proliferation, confers epithelial tumorigenesis, and promotes tumor invasion. Here we investigate the potential of PCDGF as a therapeutic target for prostate cancer. Experimental Design: We studied the expression of PC-DGF in invasive prostate cancer, adjacent high-grade prostatic intraepithelial neoplasia (PIN), and benign prostate tissue from 99 human prostate specimens. The level of PC-DGF expression was correlated with various clinicopathological characteristics. Results: Normal prostate tissue did not express (53/99), or expressed low levels (46/99) of PCDGF. In the 46 normal prostate specimens that expressed PCDGF, most of them had less than 10% of cells expressing PCDGF. PCDGF expression could be detected in more than 50% of cells in all specimens of PIN and invasive prostate cancer. The expression of PCDGF in normal prostate tissue was much less intense and in a smaller fraction of cells than in PIN and invasive adenocarcinoma (P < 0.0001). There was no correlation of PCDGF expression with age, Gleason score, pathological stage, status of lymph node metastasis, extraprostatic extension, perineural invasion, surgical margins, and vascular invasion. Conclusions: Our data suggest that the induction of PCDGF expression occurs during the development of PIN. PCDGF may be a new molecular target for the treatment and prevention of prostate cancer.
AB - Purpose: PCDGF (PC cell-derived growth factor), also called progranulin, is a Mr 88,000 glycoprotein precursor of granulin. It is a novel growth factor that stimulates cell proliferation, confers epithelial tumorigenesis, and promotes tumor invasion. Here we investigate the potential of PCDGF as a therapeutic target for prostate cancer. Experimental Design: We studied the expression of PC-DGF in invasive prostate cancer, adjacent high-grade prostatic intraepithelial neoplasia (PIN), and benign prostate tissue from 99 human prostate specimens. The level of PC-DGF expression was correlated with various clinicopathological characteristics. Results: Normal prostate tissue did not express (53/99), or expressed low levels (46/99) of PCDGF. In the 46 normal prostate specimens that expressed PCDGF, most of them had less than 10% of cells expressing PCDGF. PCDGF expression could be detected in more than 50% of cells in all specimens of PIN and invasive prostate cancer. The expression of PCDGF in normal prostate tissue was much less intense and in a smaller fraction of cells than in PIN and invasive adenocarcinoma (P < 0.0001). There was no correlation of PCDGF expression with age, Gleason score, pathological stage, status of lymph node metastasis, extraprostatic extension, perineural invasion, surgical margins, and vascular invasion. Conclusions: Our data suggest that the induction of PCDGF expression occurs during the development of PIN. PCDGF may be a new molecular target for the treatment and prevention of prostate cancer.
UR - http://www.scopus.com/inward/record.url?scp=12144287050&partnerID=8YFLogxK
U2 - 10.1158/1078-0432.CCR-1123-03
DO - 10.1158/1078-0432.CCR-1123-03
M3 - Article
C2 - 14977833
AN - SCOPUS:12144287050
SN - 1078-0432
VL - 10
SP - 1333
EP - 1337
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 4
ER -