Patterns of peripheral neuropathy in ART-naïve patients initiating modern ART regimen

Anthony J. Lee; Ronald J. Bosch; Scott R. Evans; Kunling Wu; Taylor Harrison; Philip Grant; David B. Clifford

doi:10.1007/s13365-015-0327-1

Patterns of peripheral neuropathy in ART-naïve patients initiating modern ART regimen

Anthony J. Lee, Ronald J. Bosch, Scott R. Evans, Kunling Wu, Taylor Harrison, Philip Grant, David B. Clifford

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The purpose of this study was to evaluate associations of pre-ART CD4 with peripheral neuropathy (PN) and estimate the prevalence of PN in HIV-positive patients starting modern combination antiretroviral therapy (cART) regimens. ART-naïve subjects initiating cART were followed longitudinally and screened for signs/symptoms of PN. Lower pre-ART CD4 count was associated with post-ART PN. After 7 years (n = 117), the prevalence (95 % CI) of PN and SPN were 31 % (23, 40 %) and 5 % (2, 11 %) with pre-ART CD4 count >250 copies/μL. PN continues to be identified in HIV-infected individuals on modern cART by targeted assessment but is generally without symptoms.

Original language	English
Pages (from-to)	210-218
Number of pages	9
Journal	Journal of NeuroVirology
Volume	21
Issue number	2
DOIs	https://doi.org/10.1007/s13365-015-0327-1
State	Published - Apr 1 2015

Keywords

HIV
Higher pre-ART CD4 count
Modern non-neurotoxic ART
Peripheral neuropathy
Risk factors
Symptomatic peripheral neuropathy

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10.1007/s13365-015-0327-1

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title = "Patterns of peripheral neuropathy in ART-na{\"i}ve patients initiating modern ART regimen",

abstract = "The purpose of this study was to evaluate associations of pre-ART CD4 with peripheral neuropathy (PN) and estimate the prevalence of PN in HIV-positive patients starting modern combination antiretroviral therapy (cART) regimens. ART-na{\"i}ve subjects initiating cART were followed longitudinally and screened for signs/symptoms of PN. Lower pre-ART CD4 count was associated with post-ART PN. After 7 years (n = 117), the prevalence (95 % CI) of PN and SPN were 31 % (23, 40 %) and 5 % (2, 11 %) with pre-ART CD4 count >250 copies/μL. PN continues to be identified in HIV-infected individuals on modern cART by targeted assessment but is generally without symptoms.",

keywords = "HIV, Higher pre-ART CD4 count, Modern non-neurotoxic ART, Peripheral neuropathy, Risk factors, Symptomatic peripheral neuropathy",

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AU - Lee, Anthony J.

AU - Bosch, Ronald J.

AU - Evans, Scott R.

AU - Wu, Kunling

AU - Harrison, Taylor

AU - Grant, Philip

AU - Clifford, David B.

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AB - The purpose of this study was to evaluate associations of pre-ART CD4 with peripheral neuropathy (PN) and estimate the prevalence of PN in HIV-positive patients starting modern combination antiretroviral therapy (cART) regimens. ART-naïve subjects initiating cART were followed longitudinally and screened for signs/symptoms of PN. Lower pre-ART CD4 count was associated with post-ART PN. After 7 years (n = 117), the prevalence (95 % CI) of PN and SPN were 31 % (23, 40 %) and 5 % (2, 11 %) with pre-ART CD4 count >250 copies/μL. PN continues to be identified in HIV-infected individuals on modern cART by targeted assessment but is generally without symptoms.

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KW - Risk factors

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Patterns of peripheral neuropathy in ART-naïve patients initiating modern ART regimen

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Keywords

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