Patterns of peripheral neuropathy in ART-naïve patients initiating modern ART regimen

Anthony J. Lee, Ronald J. Bosch, Scott R. Evans, Kunling Wu, Taylor Harrison, Philip Grant, David B. Clifford

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


The purpose of this study was to evaluate associations of pre-ART CD4 with peripheral neuropathy (PN) and estimate the prevalence of PN in HIV-positive patients starting modern combination antiretroviral therapy (cART) regimens. ART-naïve subjects initiating cART were followed longitudinally and screened for signs/symptoms of PN. Lower pre-ART CD4 count was associated with post-ART PN. After 7 years (n = 117), the prevalence (95 % CI) of PN and SPN were 31 % (23, 40 %) and 5 % (2, 11 %) with pre-ART CD4 count >250 copies/μL. PN continues to be identified in HIV-infected individuals on modern cART by targeted assessment but is generally without symptoms.

Original languageEnglish
Pages (from-to)210-218
Number of pages9
JournalJournal of NeuroVirology
Issue number2
StatePublished - Apr 1 2015


  • HIV
  • Higher pre-ART CD4 count
  • Modern non-neurotoxic ART
  • Peripheral neuropathy
  • Risk factors
  • Symptomatic peripheral neuropathy


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