@article{4b7aad62ffc647c1ae5d752be219b0f0,
title = "Patterns of mutations in TP53 mutated AML",
abstract = "TP53 mutated acute myeloid leukemia (AML) responds poorly to chemotherapy and has a short overall survival rate with a median of 5–9 months. Poor outcomes in TP53 mutated AML following chemotherapy have been observed and treatment options remain limited, although the presence of TP53 mutations alone should not be a barrier to therapy. Decitabine is emerging as an alternative treatment option for patients with TP53 mutated AML, although the agent has not been associated with deep molecular remissions and requires additional consolidation. The clinical and genomic characteristics of TP53 mutated AML are reviewed in this paper.",
keywords = "AML, Acute myeloid leukemia, CHIP, Clonal hematopoiesis of indeterminate potential, Decitabine, MDS, Mutation patterns, Myelodysplastic syndromes, TP53",
author = "Welch, {John S.}",
note = "Funding Information: Support was provided by NCI grants, AML-SPORE (P50 CA171963) and the Genomics of AML Program Project grant (P01 CA101937) and by NHLBI (R01 HL128447). We thank Theresa Fletcher, Megan Haney, Shannon Kramer, Sharon Heath, Kierstin Luber, Megan Janke, and Paige Schnoebelen for assistance in patient enrollment, sample collection, and clinical data processing and Greg Malnassy, Nichole Helton, and the Washington University Tissue Procurement Core for sample storage and sample preparation. Funding Information: Support was provided by NCI grants, AML-SPORE (P50 CA171963) and the Genomics of AML Program Project grant ( P01 CA101937 ) and by NHLBI ( R01 HL128447 ). We thank Theresa Fletcher, Megan Haney, Shannon Kramer, Sharon Heath, Kierstin Luber, Megan Janke, and Paige Schnoebelen for assistance in patient enrollment, sample collection, and clinical data processing and Greg Malnassy, Nichole Helton, and the Washington University Tissue Procurement Core for sample storage and sample preparation. Publisher Copyright: {\textcopyright} 2018",
year = "2018",
month = dec,
doi = "10.1016/j.beha.2018.09.010",
language = "English",
volume = "31",
pages = "379--383",
journal = "Best Practice and Research: Clinical Haematology",
issn = "1521-6926",
number = "4",
}