TY - JOUR
T1 - Patterns of local breast cancer recurrence after skin-sparing mastectomy and immediate breast reconstruction
AU - Vaughan, Aislinn
AU - Dietz, Jill R.
AU - Aft, Rebecca
AU - Gillanders, William E.
AU - Eberlein, Timothy J.
AU - Freer, Phoebe
AU - Margenthaler, Julie A.
PY - 2007/10
Y1 - 2007/10
N2 - Background: Local recurrence rates after skin-sparing mastectomy and immediate reconstruction are similar to recurrence rates after conventional mastectomy. We investigated the pattern of local recurrences and risk factors associated with them. Methods: We identified 206 patients who underwent 210 skin-sparing mastectomies with immediate reconstruction from 1998 to 2006 in our database. Results: Eleven patients had local recurrences (5.3%). Nine developed in the quadrant of the corresponding primary tumor. There were no significant differences between patients who recurred and those who did not with respect to tumor size/stage, margin status, estrogen receptor/progesterone receptor/Her2neu status, lymph node metastases, or radiation therapy (P > .05). Patients with grade 3 invasive tumors or high-grade ductal carcinoma in situ were more likely to recur than patients with grade 1 or 2 invasive tumors or low- or intermediate-grade ductal carcinoma in situ (P = .0035). Those patients who recurred had a significantly decreased overall survival compared to patients who did not recur (P = .0006). Conclusions: Skin-sparing mastectomy and immediate reconstruction has a low local recurrence rate. Recurrences occur most commonly in the same quadrant as the primary tumor and treatment approaches include surgery, chemotherapy, and radiation therapy. Local recurrence portends a poorer overall survival.
AB - Background: Local recurrence rates after skin-sparing mastectomy and immediate reconstruction are similar to recurrence rates after conventional mastectomy. We investigated the pattern of local recurrences and risk factors associated with them. Methods: We identified 206 patients who underwent 210 skin-sparing mastectomies with immediate reconstruction from 1998 to 2006 in our database. Results: Eleven patients had local recurrences (5.3%). Nine developed in the quadrant of the corresponding primary tumor. There were no significant differences between patients who recurred and those who did not with respect to tumor size/stage, margin status, estrogen receptor/progesterone receptor/Her2neu status, lymph node metastases, or radiation therapy (P > .05). Patients with grade 3 invasive tumors or high-grade ductal carcinoma in situ were more likely to recur than patients with grade 1 or 2 invasive tumors or low- or intermediate-grade ductal carcinoma in situ (P = .0035). Those patients who recurred had a significantly decreased overall survival compared to patients who did not recur (P = .0006). Conclusions: Skin-sparing mastectomy and immediate reconstruction has a low local recurrence rate. Recurrences occur most commonly in the same quadrant as the primary tumor and treatment approaches include surgery, chemotherapy, and radiation therapy. Local recurrence portends a poorer overall survival.
KW - Breast cancer
KW - Immediate breast reconstruction
KW - Local recurrence
KW - Skin-sparing mastectomy
UR - http://www.scopus.com/inward/record.url?scp=34548460641&partnerID=8YFLogxK
U2 - 10.1016/j.amjsurg.2007.06.011
DO - 10.1016/j.amjsurg.2007.06.011
M3 - Article
C2 - 17826052
AN - SCOPUS:34548460641
SN - 0002-9610
VL - 194
SP - 438
EP - 443
JO - American journal of surgery
JF - American journal of surgery
IS - 4
ER -