Patterns of care and survival outcomes for laryngeal small cell cancer

Alexander J. Lin; Prashant Gabani; Ben Fischer-Valuck; Soumon Rudra; Hiram Gay; Mackenzie Daly; Peter Oppelt; Ryan Jackson; Jason Rich; Randal Paniello; Jose Zevallos; Douglas Adkins; Wade Thorstad

doi:10.1002/hed.25430

Patterns of care and survival outcomes for laryngeal small cell cancer

Alexander J. Lin, Prashant Gabani, Ben Fischer-Valuck, Soumon Rudra, Hiram Gay, Mackenzie Daly, Peter Oppelt, Ryan Jackson, Jason Rich, Randal Paniello, Jose Zevallos, Douglas Adkins, Wade Thorstad

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: To determine practice patterns and outcomes of laryngeal small cell cancer (LSCC) across the United States. Methods: Patients with LSCC were identified in the National Cancer Database. Overall survival (OS) was compared with Kaplan-Meier analysis and Cox regression. Results: From 2004 to 2014, the 5-year OS for early stage (n = 47), locally advanced stage (n = 133), and metastatic disease (n = 53) was 34%, 26%, and 9%, respectively. Chemoradiation was given in 66% of cases. Chemotherapy was less likely given in early stage disease (P =.001), and definitive radiation was less likely given in metastatic disease (P <.001). Definitive radiation improved median OS in locally advanced LSCC (20 vs. 7 months, log-rank P =.04). In multivariable modeling, radiation dose ≥40 Gy was associated with better OS (P <.001). Conclusion: Chemoradiation was the most common practice for treating locally advanced LSCC, and radiation dose ≥40 Gy was associated with improved OS.

Original language	English
Pages (from-to)	722-729
Number of pages	8
Journal	Head and Neck
Volume	41
Issue number	3
DOIs	https://doi.org/10.1002/hed.25430
State	Published - Mar 1 2019

Keywords

chemotherapy
head and neck
neuroendocrine cancer
radiation
surgery

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title = "Patterns of care and survival outcomes for laryngeal small cell cancer",

abstract = "Background: To determine practice patterns and outcomes of laryngeal small cell cancer (LSCC) across the United States. Methods: Patients with LSCC were identified in the National Cancer Database. Overall survival (OS) was compared with Kaplan-Meier analysis and Cox regression. Results: From 2004 to 2014, the 5-year OS for early stage (n = 47), locally advanced stage (n = 133), and metastatic disease (n = 53) was 34%, 26%, and 9%, respectively. Chemoradiation was given in 66% of cases. Chemotherapy was less likely given in early stage disease (P =.001), and definitive radiation was less likely given in metastatic disease (P <.001). Definitive radiation improved median OS in locally advanced LSCC (20 vs. 7 months, log-rank P =.04). In multivariable modeling, radiation dose ≥40 Gy was associated with better OS (P <.001). Conclusion: Chemoradiation was the most common practice for treating locally advanced LSCC, and radiation dose ≥40 Gy was associated with improved OS.",

keywords = "chemotherapy, head and neck, neuroendocrine cancer, radiation, surgery",

author = "Lin, {Alexander J.} and Prashant Gabani and Ben Fischer-Valuck and Soumon Rudra and Hiram Gay and Mackenzie Daly and Peter Oppelt and Ryan Jackson and Jason Rich and Randal Paniello and Jose Zevallos and Douglas Adkins and Wade Thorstad",

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doi = "10.1002/hed.25430",

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T1 - Patterns of care and survival outcomes for laryngeal small cell cancer

AU - Lin, Alexander J.

AU - Gabani, Prashant

AU - Fischer-Valuck, Ben

AU - Rudra, Soumon

AU - Gay, Hiram

AU - Daly, Mackenzie

AU - Oppelt, Peter

AU - Jackson, Ryan

AU - Rich, Jason

AU - Paniello, Randal

AU - Zevallos, Jose

AU - Adkins, Douglas

AU - Thorstad, Wade

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Background: To determine practice patterns and outcomes of laryngeal small cell cancer (LSCC) across the United States. Methods: Patients with LSCC were identified in the National Cancer Database. Overall survival (OS) was compared with Kaplan-Meier analysis and Cox regression. Results: From 2004 to 2014, the 5-year OS for early stage (n = 47), locally advanced stage (n = 133), and metastatic disease (n = 53) was 34%, 26%, and 9%, respectively. Chemoradiation was given in 66% of cases. Chemotherapy was less likely given in early stage disease (P =.001), and definitive radiation was less likely given in metastatic disease (P <.001). Definitive radiation improved median OS in locally advanced LSCC (20 vs. 7 months, log-rank P =.04). In multivariable modeling, radiation dose ≥40 Gy was associated with better OS (P <.001). Conclusion: Chemoradiation was the most common practice for treating locally advanced LSCC, and radiation dose ≥40 Gy was associated with improved OS.

AB - Background: To determine practice patterns and outcomes of laryngeal small cell cancer (LSCC) across the United States. Methods: Patients with LSCC were identified in the National Cancer Database. Overall survival (OS) was compared with Kaplan-Meier analysis and Cox regression. Results: From 2004 to 2014, the 5-year OS for early stage (n = 47), locally advanced stage (n = 133), and metastatic disease (n = 53) was 34%, 26%, and 9%, respectively. Chemoradiation was given in 66% of cases. Chemotherapy was less likely given in early stage disease (P =.001), and definitive radiation was less likely given in metastatic disease (P <.001). Definitive radiation improved median OS in locally advanced LSCC (20 vs. 7 months, log-rank P =.04). In multivariable modeling, radiation dose ≥40 Gy was associated with better OS (P <.001). Conclusion: Chemoradiation was the most common practice for treating locally advanced LSCC, and radiation dose ≥40 Gy was associated with improved OS.

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KW - head and neck

KW - neuroendocrine cancer

KW - radiation

KW - surgery

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DO - 10.1002/hed.25430

M3 - Article

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JO - Head and Neck

JF - Head and Neck

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Patterns of care and survival outcomes for laryngeal small cell cancer

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