TY - JOUR
T1 - Patients with Esophageal Adenocarcinoma with Prior Gastroesophageal Reflux Disease Symptoms Are Similar to Those Without Gastroesophageal Reflux Disease
T2 - A Cross-Sectional Study
AU - Chandar, Apoorva Krishna
AU - Keerthy, Komal
AU - Gupta, Rajesh
AU - Grady, William M.
AU - Canto, Marcia Irene
AU - Shaheen, Nicholas J.
AU - Thota, Prashanthi N.
AU - Iyer, Prasad G.
AU - Wang, Jean S.
AU - Falk, Gary W.
AU - Abrams, Julian A.
AU - Dumot, John
AU - Faulx, Ashley
AU - Markowitz, Sanford D.
AU - Willis, Joseph
AU - Moinova, Helen
AU - Guda, Kishore
AU - Brock, Wendy
AU - Chak, Amitabh
N1 - Publisher Copyright:
© 2024 Wolters Kluwer Health. All rights reserved.
PY - 2024/5/1
Y1 - 2024/5/1
N2 - INTRODUCTION:A substantial proportion of patients with esophageal adenocarcinoma (EAC) do not report gastroesophageal reflux disease (GERD) symptoms. This study aimed to compare the risk factor profiles and cancer stage at presentation of patients with EAC with and without prior GERD.METHODS:In this retrospective cross-sectional study, patients with EAC were divided into 2 cohorts: (i) EAC with prior GERD: patients who reported typical GERD symptoms (heartburn or regurgitation) ≥1 year before cancer diagnosis and (ii) EAC without prior GERD: patients who did not report prior GERD symptoms or reported symptoms within 1 year of their cancer diagnosis. Baseline demographics, risk factors, and cancer stage at presentation were compared between the 2 cohorts. In addition, the distribution of patients based on numbers of BE/EAC-associated risk factors (1, 2, 3, 4, and 5 or more) was examined in the symptomatic and asymptomatic cohorts.RESULTS:Over 13 years, 388 patients with EAC with prior GERD and 245 patients with EAC without prior GERD were recruited. Both groups had similar baseline demographics and risk factors, but patients with EAC with prior GERD were more likely to have a history of BE. Asymptomatic patients had more advanced disease. Patients with 3 or more BE/EAC-related risk factors formed the largest proportion of patients in both the symptomatic and asymptomatic cohorts.DISCUSSION:Patients with EAC with and without prior GERD symptoms are phenotypically similar, suggesting that BE screening efforts to prevent or detect early EAC should not be restricted to just those with GERD.
AB - INTRODUCTION:A substantial proportion of patients with esophageal adenocarcinoma (EAC) do not report gastroesophageal reflux disease (GERD) symptoms. This study aimed to compare the risk factor profiles and cancer stage at presentation of patients with EAC with and without prior GERD.METHODS:In this retrospective cross-sectional study, patients with EAC were divided into 2 cohorts: (i) EAC with prior GERD: patients who reported typical GERD symptoms (heartburn or regurgitation) ≥1 year before cancer diagnosis and (ii) EAC without prior GERD: patients who did not report prior GERD symptoms or reported symptoms within 1 year of their cancer diagnosis. Baseline demographics, risk factors, and cancer stage at presentation were compared between the 2 cohorts. In addition, the distribution of patients based on numbers of BE/EAC-associated risk factors (1, 2, 3, 4, and 5 or more) was examined in the symptomatic and asymptomatic cohorts.RESULTS:Over 13 years, 388 patients with EAC with prior GERD and 245 patients with EAC without prior GERD were recruited. Both groups had similar baseline demographics and risk factors, but patients with EAC with prior GERD were more likely to have a history of BE. Asymptomatic patients had more advanced disease. Patients with 3 or more BE/EAC-related risk factors formed the largest proportion of patients in both the symptomatic and asymptomatic cohorts.DISCUSSION:Patients with EAC with and without prior GERD symptoms are phenotypically similar, suggesting that BE screening efforts to prevent or detect early EAC should not be restricted to just those with GERD.
KW - Barrett's esophagus
KW - esophageal adenocarcinoma
KW - gastroesophageal junction adenocarcinoma
KW - gastroesophageal reflux disease
UR - http://www.scopus.com/inward/record.url?scp=85192114202&partnerID=8YFLogxK
U2 - 10.14309/ajg.0000000000002593
DO - 10.14309/ajg.0000000000002593
M3 - Article
C2 - 37975600
AN - SCOPUS:85192114202
SN - 0002-9270
VL - 119
SP - 823
EP - 829
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 5
ER -