TY - GEN
T1 - Patient-specific biomechanical modeling of ventricular enlargement in hydrocephalus from longitudinal magnetic resonance imaging
AU - Chen, Yasheng
AU - Fan, Zheng
AU - Ji, Songbai
AU - Muenzer, Joseph
AU - An, Hongyu
AU - Lin, Weili
PY - 2013
Y1 - 2013
N2 - Ogden type of hyperelastic constitutive law has recently emerged in modeling ventricular enlargement in hydrocephalic brain with finite element method, but this material property for brain tissue has not been investigated in a patient-specific setting in hydrocephalus. Consequently, the accuracy of the simulated ventricular enlargement using this hyperelastic tissue property remains unknown. In this study, we evaluated this brain material model in four patients with communicating hydrocephalus under a small trans-mantle pressure difference (TPMD) between brain ventricle and subarachnoid space (<1mmHg). Based upon changes in ventricular geometries obtained with sequential MRI, we found that this hyper-elastic model has a great flexibility and accuracy in modeling ventricular enlargement (with errors less than 1mm). Our study supports the utility of this hyperelastic constitutive law for future hydrocephalus modeling and suggests that the observed ventricular enlargement in these patients may be caused by a slight increase in TMPD.
AB - Ogden type of hyperelastic constitutive law has recently emerged in modeling ventricular enlargement in hydrocephalic brain with finite element method, but this material property for brain tissue has not been investigated in a patient-specific setting in hydrocephalus. Consequently, the accuracy of the simulated ventricular enlargement using this hyperelastic tissue property remains unknown. In this study, we evaluated this brain material model in four patients with communicating hydrocephalus under a small trans-mantle pressure difference (TPMD) between brain ventricle and subarachnoid space (<1mmHg). Based upon changes in ventricular geometries obtained with sequential MRI, we found that this hyper-elastic model has a great flexibility and accuracy in modeling ventricular enlargement (with errors less than 1mm). Our study supports the utility of this hyperelastic constitutive law for future hydrocephalus modeling and suggests that the observed ventricular enlargement in these patients may be caused by a slight increase in TMPD.
KW - Brain finite element modeling
KW - Brain mechanics
KW - Finite element analysis
KW - Hydrocephalus
KW - Hyper-elastic brain modeling
KW - Ventricular enlargement
UR - http://www.scopus.com/inward/record.url?scp=84894636627&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-40760-4_37
DO - 10.1007/978-3-642-40760-4_37
M3 - Conference contribution
C2 - 24505773
AN - SCOPUS:84894636627
SN - 9783642407598
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 291
EP - 298
BT - Medical Image Computing and Computer-Assisted Intervention, MICCAI 2013 - 16th International Conference, Proceedings
T2 - 16th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2013
Y2 - 22 September 2013 through 26 September 2013
ER -