Pathways of corneal and ocular surface inflammation: A perspective from the Cullen symposium

Alison M. McDermott, Victor Perez, Andrew J.W. Huang, Stephen C. Pflugfelder, Michael E. Stern, Christophe Baudouin, Roger W. Beuerman, Alan R. Burns, Virginia L. Calder, Margarita Calonge, James Chodosh, Douglas J. Coster, Reza Dana, Linda D. Hazlett, Dan B. Jones, Stella K. Kim, Erich Knop, De Quan Li, Bradley M. Mitchell, Jerry Y. NiederkornEric Pearlman, Kirk R. Wilhelmus, Elaine Kurie

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations


The goal of this symposium was to coalesce information presented by 22 investigators in the field of corneal and ocular surface inflammation into common pathways of inflammation. The perspective elucidated in this article defines the components of the normal ocular surface immune architecture and describes the consensus reached on the mechanisms/pathways involved in 1) acute inflammation; 2) late-stage (chronic) response; and 3) allergic disease. Seven diagrams didactically illustrate mechanisms. This paper is the introductory article in a supplement containing 18 articles by the symposium participants.

Original languageEnglish
Pages (from-to)S131-S138
JournalOcular Surface
Issue number4
StatePublished - Oct 1 2005


  • Allergy
  • Amplifying factors
  • Cell mediators
  • Conjunctival-associated lymphoid tissue
  • Cullen symposium on corneal and ocular surface inflammation
  • Inflammation
  • Ocular surface inflammation
  • Signaling pathways


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