Pathophysiology, treatment, and prevention of catheter-associated urinary tract infection

Ana Flores-Mireles, Teri N. Hreha, David A. Hunstad

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


Urinary tract infections (UTIs) are among the most common microbial infections in humans and represent a substantial burden on the health care system. UTIs can be uncomplicated, as when affecting healthy individuals, or complicated, when affecting individuals with compromised urodynamics and/or host defenses, such as those with a urinary catheter. There are clear differences between uncomplicated UTI and catheter-associated UTI (CAUTI) in clinical manifestations, causative organisms, and pathophysiology. Therefore, uncomplicated UTI and CAUTI cannot be approached similarly, or the risk of complications and treatment failure may increase. It is imperative to understand the key aspects of each condition to develop successful treatment options and improve patient outcomes. Here, we will review the epidemiology, pathogen prevalence, differential mechanisms used by uropathogens, and treatment and prevention of uncomplicated UTI and CAUTI.

Original languageEnglish
Pages (from-to)228-240
Number of pages13
JournalTopics in Spinal Cord Injury Rehabilitation
Issue number3
StatePublished - 2019


  • Prevalence
  • Susceptibility
  • Uncomplicated UTI
  • Uropathogens


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