Pathophysiology of parkinsonism due to hydrocephalus

B. A. Racette; G. J. Esper; J. Antenor; K. J. Black; A. Burkey; S. M. Moerlein; T. O. Videen; V. Kotagal; J. G. Ojemann; J. S. Perlmutter

doi:10.1136/jnnp.2003.028449

Pathophysiology of parkinsonism due to hydrocephalus

B. A. Racette
, G. J. Esper
, J. Antenor
, K. J. Black
, A. Burkey
, S. M. Moerlein
, T. O. Videen
, V. Kotagal
, J. G. Ojemann
, J. S. Perlmutter

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

We report a patient with hydrocephalus who developed levodopa responsive parkinsonism and severe bradyphrenia associated with shunt malfunction and revision. Magnetic resonance imaging revealed periaqueductal edema involving medial substantia nigra. [¹⁸F]dopa positron emission tomography demonstrated reduced uptake in the caudate and putamen with relative sparing of the posterior putamen. Hydrocephalus associated with shunt malfunction can cause a distinct parkinsonian syndrome with greater dysfunction of projections from the medial substantia nigra to anterior striatum than in idiopathic Parkinson's disease.

Original language	English
Pages (from-to)	1617-1619
Number of pages	3
Journal	Journal of Neurology, Neurosurgery and Psychiatry
Volume	75
Issue number	11
DOIs	https://doi.org/10.1136/jnnp.2003.028449
State	Published - Nov 2004

Access to Document

10.1136/jnnp.2003.028449

Cite this

@article{488dcd324178476b82596e682192f213,

title = "Pathophysiology of parkinsonism due to hydrocephalus",

abstract = "We report a patient with hydrocephalus who developed levodopa responsive parkinsonism and severe bradyphrenia associated with shunt malfunction and revision. Magnetic resonance imaging revealed periaqueductal edema involving medial substantia nigra. [18F]dopa positron emission tomography demonstrated reduced uptake in the caudate and putamen with relative sparing of the posterior putamen. Hydrocephalus associated with shunt malfunction can cause a distinct parkinsonian syndrome with greater dysfunction of projections from the medial substantia nigra to anterior striatum than in idiopathic Parkinson's disease.",

author = "Racette, \{B. A.\} and Esper, \{G. J.\} and J. Antenor and Black, \{K. J.\} and A. Burkey and Moerlein, \{S. M.\} and Videen, \{T. O.\} and V. Kotagal and Ojemann, \{J. G.\} and Perlmutter, \{J. S.\}",

year = "2004",

month = nov,

doi = "10.1136/jnnp.2003.028449",

language = "English",

volume = "75",

pages = "1617--1619",

journal = "Journal of Neurology, Neurosurgery and Psychiatry",

issn = "0022-3050",

number = "11",

}

TY - JOUR

T1 - Pathophysiology of parkinsonism due to hydrocephalus

AU - Racette, B. A.

AU - Esper, G. J.

AU - Antenor, J.

AU - Black, K. J.

AU - Burkey, A.

AU - Moerlein, S. M.

AU - Videen, T. O.

AU - Kotagal, V.

AU - Ojemann, J. G.

AU - Perlmutter, J. S.

PY - 2004/11

Y1 - 2004/11

N2 - We report a patient with hydrocephalus who developed levodopa responsive parkinsonism and severe bradyphrenia associated with shunt malfunction and revision. Magnetic resonance imaging revealed periaqueductal edema involving medial substantia nigra. [18F]dopa positron emission tomography demonstrated reduced uptake in the caudate and putamen with relative sparing of the posterior putamen. Hydrocephalus associated with shunt malfunction can cause a distinct parkinsonian syndrome with greater dysfunction of projections from the medial substantia nigra to anterior striatum than in idiopathic Parkinson's disease.

AB - We report a patient with hydrocephalus who developed levodopa responsive parkinsonism and severe bradyphrenia associated with shunt malfunction and revision. Magnetic resonance imaging revealed periaqueductal edema involving medial substantia nigra. [18F]dopa positron emission tomography demonstrated reduced uptake in the caudate and putamen with relative sparing of the posterior putamen. Hydrocephalus associated with shunt malfunction can cause a distinct parkinsonian syndrome with greater dysfunction of projections from the medial substantia nigra to anterior striatum than in idiopathic Parkinson's disease.

UR - https://www.scopus.com/pages/publications/7244219833

U2 - 10.1136/jnnp.2003.028449

DO - 10.1136/jnnp.2003.028449

M3 - Article

C2 - 15489399

AN - SCOPUS:7244219833

SN - 0022-3050

VL - 75

SP - 1617

EP - 1619

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

IS - 11

ER -

Pathophysiology of parkinsonism due to hydrocephalus

Abstract

Access to Document

Other files and links

Fingerprint

Cite this