Pathophysiology of parkinsonism due to hydrocephalus

B. A. Racette, G. J. Esper, J. Antenor, K. J. Black, A. Burkey, S. M. Moerlein, T. O. Videen, V. Kotagal, J. G. Ojemann, J. S. Perlmutter

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


We report a patient with hydrocephalus who developed levodopa responsive parkinsonism and severe bradyphrenia associated with shunt malfunction and revision. Magnetic resonance imaging revealed periaqueductal edema involving medial substantia nigra. [18F]dopa positron emission tomography demonstrated reduced uptake in the caudate and putamen with relative sparing of the posterior putamen. Hydrocephalus associated with shunt malfunction can cause a distinct parkinsonian syndrome with greater dysfunction of projections from the medial substantia nigra to anterior striatum than in idiopathic Parkinson's disease.

Original languageEnglish
Pages (from-to)1617-1619
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number11
StatePublished - Nov 2004


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