TY - JOUR
T1 - Pathophysiology of Diseases Involving Intestinal Brush-Border Proteins
AU - Alpers, David H.
AU - Seetharam, Bellur
PY - 1977/5/5
Y1 - 1977/5/5
N2 - The intestinal brush border is a complex organelle that contains hydrolytic enzymes, receptors, other proteins involved in transport and contractile proteins. In this article, we review the molecular organization of brush-border proteins within the whole membrane, and discuss their synthesis and turnover. This knowledge provides a framework for understanding the mechanisms by which certain diseases are associated with changes in brush-border proteins. Distribution of Enzymes within the Brush Border The intestinal brush border is composed of a membranous sheet, 6.0 nm wide, lined on the luminal side by a carbohydrate-rich layer known as the glycocalyx (Fig. 1). Attached to the.
AB - The intestinal brush border is a complex organelle that contains hydrolytic enzymes, receptors, other proteins involved in transport and contractile proteins. In this article, we review the molecular organization of brush-border proteins within the whole membrane, and discuss their synthesis and turnover. This knowledge provides a framework for understanding the mechanisms by which certain diseases are associated with changes in brush-border proteins. Distribution of Enzymes within the Brush Border The intestinal brush border is composed of a membranous sheet, 6.0 nm wide, lined on the luminal side by a carbohydrate-rich layer known as the glycocalyx (Fig. 1). Attached to the.
UR - http://www.scopus.com/inward/record.url?scp=0017579120&partnerID=8YFLogxK
U2 - 10.1056/NEJM197705052961808
DO - 10.1056/NEJM197705052961808
M3 - Review article
C2 - 321966
AN - SCOPUS:0017579120
VL - 296
SP - 1047
EP - 1050
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 0028-4793
IS - 18
ER -