Pathophysiology of Diseases Involving Intestinal Brush-Border Proteins

David H. Alpers, Bellur Seetharam

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


The intestinal brush border is a complex organelle that contains hydrolytic enzymes, receptors, other proteins involved in transport and contractile proteins. In this article, we review the molecular organization of brush-border proteins within the whole membrane, and discuss their synthesis and turnover. This knowledge provides a framework for understanding the mechanisms by which certain diseases are associated with changes in brush-border proteins. Distribution of Enzymes within the Brush Border The intestinal brush border is composed of a membranous sheet, 6.0 nm wide, lined on the luminal side by a carbohydrate-rich layer known as the glycocalyx (Fig. 1). Attached to the.

Original languageEnglish
Pages (from-to)1047-1050
Number of pages4
JournalNew England Journal of Medicine
Issue number18
StatePublished - May 5 1977


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