Pathology of immunodeficient mice with naturally occurring murine norovirus infection

Jerrold M. Ward, Christiane E. Wobus, Larissa B. Thackray, Cindy R. Erexson, Larry J. Faucette, Gaël Belliot, Elyssa L. Barron, Stanislav V. Sosnovtsev, Kim Y. Green

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

Murine norovirus (MNV) was recently discovered in Rag2-/-/ Stat1-/- mice in a U.S. medical research facility. Presently, little is known concerning the epidemiology and natural history of this virus. We studied the pathology of naturally occurring MNV infection in 28 immunodeficient mice of several different genotypes (Rag1-/-/IFNγ R -/-, OT1 Rag1-/-/IFNγ R-/-, OT2 Rag1 -/-/IFNγ R-/-, Rag1-/-/Stat1 -/-, and Rag2-/-) that were maintained in two U.S. research facilities. The mice were selected for study because sentinel mice housed in their holding rooms had been identified as positive for MNV-specific antibodies during routine screening for infectious agents. Our data indicate that in certain lines of immunodeficient mice, MNV can establish a disseminated infection that is characteristically associated with inflammation in multiple tissues, including liver (hepatitis), lung (focal interstitial pneumonia) and the peritoneal and pleural cavities. In addition, MNV can establish an asymptomatic infection in the mesenteric lymph nodes of Rag2-/- mice. Further studies are needed to determine whether MNV presents a confounding variable in immunological, toxicological and pathological studies in mice naturally infected with MNV. [The supplemental data referenced in this paper is not printed in this issue of Toxicologic Pathology. It is available as a downloadable file in the online edition of Toxicologic Pathology, 34(6). In order to access the full article online, you must have either an individual subscription or a member subscription accessed through www.toxpath.org.]

Original languageEnglish
Pages (from-to)708-715
Number of pages8
JournalToxicologic Pathology
Volume34
Issue number6
DOIs
StatePublished - Oct 1 2006

Keywords

  • Caliciviruses
  • Dendritic cells
  • Hepatitis
  • Immunodeficient mice
  • Murine norovirus
  • Pneumonia

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